1dps
From Proteopedia
(New page: 200px<br /><applet load="1dps" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dps, resolution 1.60Å" /> '''THE CRYSTAL STRUCTUR...) |
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| - | [[Image:1dps.jpg|left|200px]]<br /><applet load="1dps" size=" | + | [[Image:1dps.jpg|left|200px]]<br /><applet load="1dps" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1dps, resolution 1.60Å" /> | caption="1dps, resolution 1.60Å" /> | ||
'''THE CRYSTAL STRUCTURE OF DPS, A FERRITIN HOMOLOG THAT BINDS AND PROTECTS DNA'''<br /> | '''THE CRYSTAL STRUCTURE OF DPS, A FERRITIN HOMOLOG THAT BINDS AND PROTECTS DNA'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of Dps, a DNA-binding protein from starved E. coli | + | The crystal structure of Dps, a DNA-binding protein from starved E. coli that protects DNA from oxidative damage, has been solved at 1.6 A resolution. The Dps monomer has essentially the same fold as ferritin, which forms a 24-mer with 432 symmetry, a hollow core and pores at the three-fold axes. Dps forms a dodecamer with 23 (tetrahedral) point group symmetry which also has a hollow core and pores at the three-folds. The structure suggests a novel DNA-binding motif and a mechanism for DNA protection based on the sequestration of Fe ions. |
==About this Structure== | ==About this Structure== | ||
| - | 1DPS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1DPS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DPS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Filman, D | + | [[Category: Filman, D J.]] |
| - | [[Category: Finkel, S | + | [[Category: Finkel, S E.]] |
| - | [[Category: Grant, R | + | [[Category: Grant, R A.]] |
| - | [[Category: Hogle, J | + | [[Category: Hogle, J M.]] |
[[Category: Kolter, R.]] | [[Category: Kolter, R.]] | ||
[[Category: NA]] | [[Category: NA]] | ||
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[[Category: stationary phase]] | [[Category: stationary phase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:19:10 2008'' |
Revision as of 10:19, 21 February 2008
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THE CRYSTAL STRUCTURE OF DPS, A FERRITIN HOMOLOG THAT BINDS AND PROTECTS DNA
Overview
The crystal structure of Dps, a DNA-binding protein from starved E. coli that protects DNA from oxidative damage, has been solved at 1.6 A resolution. The Dps monomer has essentially the same fold as ferritin, which forms a 24-mer with 432 symmetry, a hollow core and pores at the three-fold axes. Dps forms a dodecamer with 23 (tetrahedral) point group symmetry which also has a hollow core and pores at the three-folds. The structure suggests a novel DNA-binding motif and a mechanism for DNA protection based on the sequestration of Fe ions.
About this Structure
1DPS is a Single protein structure of sequence from Escherichia coli with as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of Dps, a ferritin homolog that binds and protects DNA., Grant RA, Filman DJ, Finkel SE, Kolter R, Hogle JM, Nat Struct Biol. 1998 Apr;5(4):294-303. PMID:9546221
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