2jdk

From Proteopedia

Revision as of 10:39, 30 October 2007

LECTIN PA-IIL OF P.AERUGINOSA COMPLEXED WITH DISACCHARIDE DERIVATIVE

Overview

Pseudomonas aeruginosa is an opportunistic bacterium showing increasing, resistance to antibiotics and consequently represents elevated threatening, problems in hospital environments, particularly for cystic fibrosis, patients. The use of glycomimetics as an anti-adhesive strategy against, microorganisms may complement the use of antibiotics. PA-IIL lectin (LecB), from P. aeruginosa constitutes an appealing target for antibacterial, agents, as it has been proposed to play a key role in binding to airway, epithelia and/or to be involved in biofilm formation. The lectin has an, unusually high affinity for L-fucose and related oligosaccharides. In the, work presented herein, the disaccharide alphaFuc1-4GlcNAc is used as a, scaffold toward the synthesis of a series of glycomimetic ... [(full description)]

About this Structure

2JDK is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with FUC, CA and SO4 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

X-ray Structures and Thermodynamics of the Interaction of PA-IIL from Pseudomonas aeruginosa with Disaccharide Derivatives., Marotte K, Sabin C, Preville C, Moume-Pymbock M, Wimmerova M, Mitchell EP, Imberty A, Roy R, ChemMedChem. 2007 Jul 10;. PMID:17623286

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