1elo
From Proteopedia
(New page: 200px<br /><applet load="1elo" size="450" color="white" frame="true" align="right" spinBox="true" caption="1elo, resolution 2.8Å" /> '''ELONGATION FACTOR G W...) |
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| - | [[Image:1elo.gif|left|200px]]<br /><applet load="1elo" size=" | + | [[Image:1elo.gif|left|200px]]<br /><applet load="1elo" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1elo, resolution 2.8Å" /> | caption="1elo, resolution 2.8Å" /> | ||
'''ELONGATION FACTOR G WITHOUT NUCLEOTIDE'''<br /> | '''ELONGATION FACTOR G WITHOUT NUCLEOTIDE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of Thermus thermophilus elongation factor G without | + | The crystal structure of Thermus thermophilus elongation factor G without guanine nucleotide was determined to 2.85 A. This GTPase has five domains with overall dimensions of 50 x 60 x 118 A. The GTP binding domain has a core common to other GTPases with a unique subdomain which probably functions as an intrinsic nucleotide exchange factor. Domains I and II are homologous to elongation factor Tu and their arrangement, both with and without GDP, is more similar to elongation factor Tu in complex with a GTP analogue than with GDP. Domains III and V show structural similarities to ribosomal proteins. Domain IV protrudes from the main body of the protein and has an extraordinary topology with a left-handed cross-over connection between two parallel beta-strands. |
==About this Structure== | ==About this Structure== | ||
| - | 1ELO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http:// | + | 1ELO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ELO OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Garber, M.]] | [[Category: Garber, M.]] | ||
[[Category: Liljas, A.]] | [[Category: Liljas, A.]] | ||
| - | [[Category: Svensson, L | + | [[Category: Svensson, L A.]] |
[[Category: Zheltonosova, J.]] | [[Category: Zheltonosova, J.]] | ||
[[Category: elongation factor]] | [[Category: elongation factor]] | ||
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[[Category: ribosomal translocase]] | [[Category: ribosomal translocase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:29:03 2008'' |
Revision as of 10:29, 21 February 2008
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ELONGATION FACTOR G WITHOUT NUCLEOTIDE
Overview
The crystal structure of Thermus thermophilus elongation factor G without guanine nucleotide was determined to 2.85 A. This GTPase has five domains with overall dimensions of 50 x 60 x 118 A. The GTP binding domain has a core common to other GTPases with a unique subdomain which probably functions as an intrinsic nucleotide exchange factor. Domains I and II are homologous to elongation factor Tu and their arrangement, both with and without GDP, is more similar to elongation factor Tu in complex with a GTP analogue than with GDP. Domains III and V show structural similarities to ribosomal proteins. Domain IV protrudes from the main body of the protein and has an extraordinary topology with a left-handed cross-over connection between two parallel beta-strands.
About this Structure
1ELO is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus., AEvarsson A, Brazhnikov E, Garber M, Zheltonosova J, Chirgadze Y, al-Karadaghi S, Svensson LA, Liljas A, EMBO J. 1994 Aug 15;13(16):3669-77. PMID:8070397
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