1bfe
From Proteopedia
(New page: 200px<br /> <applet load="1bfe" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bfe, resolution 2.3Å" /> '''THE THIRD PDZ DOMAIN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BFE is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BFE OCA]]. | + | 1BFE is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]]. Structure known Active Site: PEP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BFE OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: protein localization]] | [[Category: protein localization]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:46:10 2007'' |
Revision as of 10:41, 30 October 2007
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THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
Overview
Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their, C-terminus. The X-ray crystallographic structures of the third PDZ domain, from the synaptic protein PSD-95 in complex with and in the absence of its, peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms, resolution, respectively. The structures reveal that a four-residue, C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through, antiparallel main chain interactions with a beta sheet of the domain., Recognition of the terminal carboxylate group of the peptide is conferred, by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as, well as by an arginine side chain. Specific side chain interactions and a, ... [(full description)]
About this Structure
1BFE is a [Single protein] structure of sequence from [Rattus norvegicus]. Structure known Active Site: PEP. Full crystallographic information is available from [OCA].
Reference
Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ., Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R, Cell. 1996 Jun 28;85(7):1067-76. PMID:8674113
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