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1epf
From Proteopedia
(New page: 200px<br /><applet load="1epf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1epf, resolution 1.85Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size=" | + | [[Image:1epf.gif|left|200px]]<br /><applet load="1epf" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1epf, resolution 1.85Å" /> | caption="1epf, resolution 1.85Å" /> | ||
'''CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)'''<br /> | '''CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The neural cell adhesion molecule NCAM, a member of the immunoglobulin | + | The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM. |
==About this Structure== | ==About this Structure== | ||
| - | 1EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1EPF is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EPF OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bock, E.]] | [[Category: Bock, E.]] | ||
[[Category: Ikemizu, S.]] | [[Category: Ikemizu, S.]] | ||
| - | [[Category: Jones, E | + | [[Category: Jones, E Y.]] |
[[Category: Kasper, C.]] | [[Category: Kasper, C.]] | ||
| - | [[Category: Kastrup, J | + | [[Category: Kastrup, J S.]] |
| - | [[Category: Larsen, I | + | [[Category: Larsen, I K.]] |
[[Category: Rasmussen, H.]] | [[Category: Rasmussen, H.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: ncam]] | [[Category: ncam]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:16 2008'' |
Revision as of 10:30, 21 February 2008
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CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)
Overview
The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.
About this Structure
1EPF is a Single protein structure of sequence from Rattus norvegicus with as ligand. Full crystallographic information is available from OCA.
Reference
Structural basis of cell-cell adhesion by NCAM., Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Larsen IK, Nat Struct Biol. 2000 May;7(5):389-93. PMID:10802736
Page seeded by OCA on Thu Feb 21 12:30:16 2008
