1eqz
From Proteopedia
(New page: 200px<br /><applet load="1eqz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1eqz, resolution 2.50Å" /> '''X-RAY STRUCTURE OF T...) |
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- | [[Image:1eqz.gif|left|200px]]<br /><applet load="1eqz" size=" | + | [[Image:1eqz.gif|left|200px]]<br /><applet load="1eqz" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1eqz, resolution 2.50Å" /> | caption="1eqz, resolution 2.50Å" /> | ||
'''X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION'''<br /> | '''X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION'''<br /> | ||
==Overview== | ==Overview== | ||
- | The 2.5 A X-ray crystal structure of the nucleosome core particle | + | The 2.5 A X-ray crystal structure of the nucleosome core particle presented here provides significant additions to the understanding of the nucleosome, the fundamental unit of chromatin structure. Extensions are made to the structure of the N-terminal histone tails and details are provided on hydration and ion binding. The structure is composed of twofold symmetric molecules, native chicken histone octamer cores and the DNA palindrome, which were expected to form a perfectly twofold symmetric nucleosome core particle. In fact, the result is asymmetric owing to the binding of the DNA to the protein surface and to the packing of the particles in the crystal lattice. An analysis is made of the asymmetries by comparisons both within the nucleosome core particle and to the structure of the histone octamer core of the nucleosome. |
==About this Structure== | ==About this Structure== | ||
- | 1EQZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with CL, CAC, K and MN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1EQZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] with <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=CAC:'>CAC</scene>, <scene name='pdbligand=K:'>K</scene> and <scene name='pdbligand=MN:'>MN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EQZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Gallus gallus]] | [[Category: Gallus gallus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
- | [[Category: Bunick, G | + | [[Category: Bunick, G J.]] |
- | [[Category: Hanson, B | + | [[Category: Hanson, B L.]] |
- | [[Category: Harp, J | + | [[Category: Harp, J M.]] |
- | [[Category: Timm, D | + | [[Category: Timm, D E.]] |
[[Category: CAC]] | [[Category: CAC]] | ||
[[Category: CL]] | [[Category: CL]] | ||
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[[Category: nucleosome core particle]] | [[Category: nucleosome core particle]] | ||
- | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:30:44 2008'' |
Revision as of 10:30, 21 February 2008
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X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
Overview
The 2.5 A X-ray crystal structure of the nucleosome core particle presented here provides significant additions to the understanding of the nucleosome, the fundamental unit of chromatin structure. Extensions are made to the structure of the N-terminal histone tails and details are provided on hydration and ion binding. The structure is composed of twofold symmetric molecules, native chicken histone octamer cores and the DNA palindrome, which were expected to form a perfectly twofold symmetric nucleosome core particle. In fact, the result is asymmetric owing to the binding of the DNA to the protein surface and to the packing of the particles in the crystal lattice. An analysis is made of the asymmetries by comparisons both within the nucleosome core particle and to the structure of the histone octamer core of the nucleosome.
About this Structure
1EQZ is a Protein complex structure of sequences from Gallus gallus with , , and as ligands. Full crystallographic information is available from OCA.
Reference
Asymmetries in the nucleosome core particle at 2.5 A resolution., Harp JM, Hanson BL, Timm DE, Bunick GJ, Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1513-34. PMID:11092917
Page seeded by OCA on Thu Feb 21 12:30:44 2008