1gp7
From Proteopedia
(New page: 200px<br /> <applet load="1gp7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gp7, resolution 2.6Å" /> '''ACIDIC PHOSPHOLIPASE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GP7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GP7 OCA]]. | + | 1GP7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4]]. Structure known Active Site: CAA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GP7 OCA]]. |
==Reference== | ==Reference== | ||
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12217659 12217659] | Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12217659 12217659] | ||
[[Category: Ophiophagus hannah]] | [[Category: Ophiophagus hannah]] | ||
| + | [[Category: Phospholipase A(2)]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Lin, Z.]] | [[Category: Lin, Z.]] | ||
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[[Category: snake venom]] | [[Category: snake venom]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:47:17 2007'' |
Revision as of 10:42, 30 October 2007
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ACIDIC PHOSPHOLIPASE A2 FROM VENOM OF OPHIOPHAGUS HANNAH
Overview
The crystal structure of an acidic phospholipase A(2) from Ophiophagus, hannah (king cobra) has been determined by molecular replacement at 2.6-A, resolution to a crystallographic R factor of 20.5% (R(free)=23.3%) with, reasonable stereochemistry. The venom enzyme contains an unusual, "pancreatic loop." The conformation of the loop is well defined and, different from those in pancreas PLA(2), showing its structural, variability. This analysis provides the first structure of a PLA(2)-type, cardiotoxin. The sites related to the cardiotoxic and myotoxic activities, are explored and the oligomer observed in the crystalline state is, described.
About this Structure
1GP7 is a [Single protein] structure of sequence from [Ophiophagus hannah] with CA as [ligand]. Active as [Phospholipase A(2)], with EC number [3.1.1.4]. Structure known Active Site: CAA. Full crystallographic information is available from [OCA].
Reference
Structure of a cardiotoxic phospholipase A(2) from Ophiophagus hannah with the "pancreatic loop"., Zhang HL, Xu SJ, Wang QY, Song SY, Shu YY, Lin ZJ, J Struct Biol. 2002 Jun;138(3):207-15. PMID:12217659
Page seeded by OCA on Tue Oct 30 12:47:17 2007
