1ezj
From Proteopedia
(New page: 200px<br /><applet load="1ezj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ezj, resolution 1.90Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1ezj.gif|left|200px]]<br /><applet load="1ezj" size=" | + | [[Image:1ezj.gif|left|200px]]<br /><applet load="1ezj" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1ezj, resolution 1.90Å" /> | caption="1ezj, resolution 1.90Å" /> | ||
'''CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS'''<br /> | '''CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The high resolution X-ray structure of the Sendai virus oligomerization | + | The high resolution X-ray structure of the Sendai virus oligomerization domain reveals a homotetrameric coiled coil structure with many details that are different from classic coiled coils with canonical hydrophobic heptad repeats. Alternatives to the classic knobs-into-holes packing lead to differences in supercoil pitch and diameter that allow water molecules inside the core. This open and more hydrophilic structure does not seem to be destabilized by mutations that would be expected to disrupt classic coiled coils. |
==About this Structure== | ==About this Structure== | ||
| - | 1EZJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sendai_virus Sendai virus] with EMC and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http:// | + | 1EZJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sendai_virus Sendai virus] with <scene name='pdbligand=EMC:'>EMC</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EZJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Sendai virus]] | [[Category: Sendai virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Burmeister, W | + | [[Category: Burmeister, W P.]] |
[[Category: Curran, J.]] | [[Category: Curran, J.]] | ||
| - | [[Category: Ruigrok, R | + | [[Category: Ruigrok, R W.H.]] |
[[Category: Tarbouriech, N.]] | [[Category: Tarbouriech, N.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
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[[Category: viral polymerase]] | [[Category: viral polymerase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:33:16 2008'' |
Revision as of 10:33, 21 February 2008
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CRYSTAL STRUCTURE OF THE MULTIMERIZATION DOMAIN OF THE PHOSPHOPROTEIN FROM SENDAI VIRUS
Overview
The high resolution X-ray structure of the Sendai virus oligomerization domain reveals a homotetrameric coiled coil structure with many details that are different from classic coiled coils with canonical hydrophobic heptad repeats. Alternatives to the classic knobs-into-holes packing lead to differences in supercoil pitch and diameter that allow water molecules inside the core. This open and more hydrophilic structure does not seem to be destabilized by mutations that would be expected to disrupt classic coiled coils.
About this Structure
1EZJ is a Single protein structure of sequence from Sendai virus with and as ligands. Active as RNA-directed RNA polymerase, with EC number 2.7.7.48 Full crystallographic information is available from OCA.
Reference
Tetrameric coiled coil domain of Sendai virus phosphoprotein., Tarbouriech N, Curran J, Ruigrok RW, Burmeister WP, Nat Struct Biol. 2000 Sep;7(9):777-81. PMID:10966649
Page seeded by OCA on Thu Feb 21 12:33:16 2008
