1ffx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1ffx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ffx, resolution 3.95&Aring;" /> '''TUBULIN:STATHMIN-LIK...)
Line 1: Line 1:
-
[[Image:1ffx.gif|left|200px]]<br /><applet load="1ffx" size="450" color="white" frame="true" align="right" spinBox="true"
+
[[Image:1ffx.gif|left|200px]]<br /><applet load="1ffx" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1ffx, resolution 3.95&Aring;" />
caption="1ffx, resolution 3.95&Aring;" />
'''TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX'''<br />
'''TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX'''<br />
==Overview==
==Overview==
-
Phosphoproteins of the stathmin family interact with the alphabeta tubulin, heterodimer (tubulin) and hence interfere with microtubule dynamics. The, structure of the complex of GDP-tubulin with the stathmin-like domain of, the neural protein RB3 reveals a head-to-tail assembly of two tubulins, with a 91-residue RB3 alpha helix in which each copy of an internal, duplicated sequence interacts with a different tubulin. As a result of the, relative orientations adopted by tubulins and by their alpha and beta, subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix, thus most likely prevents incorporation of tubulin into microtubules by, holding it in an assembly with a curvature very similar to that of the, depolymerization products of microtubules.
+
Phosphoproteins of the stathmin family interact with the alphabeta tubulin heterodimer (tubulin) and hence interfere with microtubule dynamics. The structure of the complex of GDP-tubulin with the stathmin-like domain of the neural protein RB3 reveals a head-to-tail assembly of two tubulins with a 91-residue RB3 alpha helix in which each copy of an internal duplicated sequence interacts with a different tubulin. As a result of the relative orientations adopted by tubulins and by their alpha and beta subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix thus most likely prevents incorporation of tubulin into microtubules by holding it in an assembly with a curvature very similar to that of the depolymerization products of microtubules.
==About this Structure==
==About this Structure==
-
1FFX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with GTP and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FFX OCA].
+
1FFX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=GTP:'>GTP</scene> and <scene name='pdbligand=GDP:'>GDP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FFX OCA].
==Reference==
==Reference==
Line 25: Line 25:
[[Category: tubulin]]
[[Category: tubulin]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 14:53:54 2007''
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:38:13 2008''

Revision as of 10:38, 21 February 2008

Image:1ffx.gif

1ffx, resolution 3.95Å

Drag the structure with the mouse to rotate

TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX

Overview

Phosphoproteins of the stathmin family interact with the alphabeta tubulin heterodimer (tubulin) and hence interfere with microtubule dynamics. The structure of the complex of GDP-tubulin with the stathmin-like domain of the neural protein RB3 reveals a head-to-tail assembly of two tubulins with a 91-residue RB3 alpha helix in which each copy of an internal duplicated sequence interacts with a different tubulin. As a result of the relative orientations adopted by tubulins and by their alpha and beta subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix thus most likely prevents incorporation of tubulin into microtubules by holding it in an assembly with a curvature very similar to that of the depolymerization products of microtubules.

About this Structure

1FFX is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus with and as ligands. Full crystallographic information is available from OCA.

Reference

The 4 A X-ray structure of a tubulin:stathmin-like domain complex., Gigant B, Curmi PA, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, Cell. 2000 Sep 15;102(6):809-16. PMID:11030624

Page seeded by OCA on Thu Feb 21 12:38:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ffx"
Personal tools