1fva
From Proteopedia
(New page: 200px<br /><applet load="1fva" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fva, resolution 1.7Å" /> '''CRYSTAL STRUCTURE OF ...) |
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| - | [[Image:1fva.gif|left|200px]]<br /><applet load="1fva" size=" | + | [[Image:1fva.gif|left|200px]]<br /><applet load="1fva" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1fva, resolution 1.7Å" /> | caption="1fva, resolution 1.7Å" /> | ||
'''CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE'''<br /> | '''CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Peptide methionine sulfoxide reductase (MsrA) reverses oxidative damage to | + | Peptide methionine sulfoxide reductase (MsrA) reverses oxidative damage to both free methionine and methionine within proteins. As such, it helps protect the host organism against stochastic damage that can contribute to cell death. The structure of bovine MsrA has been determined in two different modifications, both of which provide different insights into the biology of the protein. There are three cysteine residues located in the vicinity of the active site. Conformational changes in a glycine-rich C-terminal tail appear to allow all three thiols to come together and to participate in catalysis. The structures support a unique, thiol-disulfide exchange mechanism that relies upon an essential cysteine as a nucleophile and additional conserved residues that interact with the oxygen atom of the sulfoxide moiety. |
==About this Structure== | ==About this Structure== | ||
| - | 1FVA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Active as [http://en.wikipedia.org/wiki/Peptide-methionine-(S)-S-oxide_reductase Peptide-methionine-(S)-S-oxide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.4.11 1.8.4.11] Full crystallographic information is available from [http:// | + | 1FVA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Active as [http://en.wikipedia.org/wiki/Peptide-methionine-(S)-S-oxide_reductase Peptide-methionine-(S)-S-oxide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.4.11 1.8.4.11] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FVA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Brot, N.]] | [[Category: Brot, N.]] | ||
| - | [[Category: Lowther, W | + | [[Category: Lowther, W T.]] |
| - | [[Category: Matthews, B | + | [[Category: Matthews, B W.]] |
[[Category: Weissbach, H.]] | [[Category: Weissbach, H.]] | ||
[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:43:01 2008'' |
Revision as of 10:43, 21 February 2008
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CRYSTAL STRUCTURE OF BOVINE METHIONINE SULFOXIDE REDUCTASE
Overview
Peptide methionine sulfoxide reductase (MsrA) reverses oxidative damage to both free methionine and methionine within proteins. As such, it helps protect the host organism against stochastic damage that can contribute to cell death. The structure of bovine MsrA has been determined in two different modifications, both of which provide different insights into the biology of the protein. There are three cysteine residues located in the vicinity of the active site. Conformational changes in a glycine-rich C-terminal tail appear to allow all three thiols to come together and to participate in catalysis. The structures support a unique, thiol-disulfide exchange mechanism that relies upon an essential cysteine as a nucleophile and additional conserved residues that interact with the oxygen atom of the sulfoxide moiety.
About this Structure
1FVA is a Single protein structure of sequence from Bos taurus. Active as Peptide-methionine-(S)-S-oxide reductase, with EC number 1.8.4.11 Full crystallographic information is available from OCA.
Reference
Structure and mechanism of peptide methionine sulfoxide reductase, an "anti-oxidation" enzyme., Lowther WT, Brot N, Weissbach H, Matthews BW, Biochemistry. 2000 Nov 7;39(44):13307-12. PMID:11063566
Page seeded by OCA on Thu Feb 21 12:43:01 2008
