4gsa
From Proteopedia
(New page: 200px<br /> <applet load="4gsa" size="450" color="white" frame="true" align="right" spinBox="true" caption="4gsa, resolution 2.50Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 4GSA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]] with PLP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4GSA OCA]]. | + | 4GSA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Synechococcus_sp. Synechococcus sp.]] with PLP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8]]. Structure known Active Sites: COA and COB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4GSA OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity., Hennig M, Grimm B, Contestabile R, John RA, Jansonius JN, Proc Natl Acad Sci U S A. 1997 May 13;94(10):4866-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9144156 9144156] | Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity., Hennig M, Grimm B, Contestabile R, John RA, Jansonius JN, Proc Natl Acad Sci U S A. 1997 May 13;94(10):4866-71. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9144156 9144156] | ||
| + | [[Category: Glutamate-1-semialdehyde 2,1-aminomutase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Synechococcus sp.]] | [[Category: Synechococcus sp.]] | ||
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[[Category: reduced form]] | [[Category: reduced form]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:51:56 2007'' |
Revision as of 10:47, 30 October 2007
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CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE (AMINOTRANSFERASE) REDUCED WITH CYANOBOROHYDRATE
Overview
The three-dimensional structure of glutamate-1-semialdehyde aminomutase, (EC 5.4.3.8), an alpha2-dimeric enzyme from Synechococcus, has been, determined by x-ray crystallography using heavy atom derivative phasing., The structure, refined at 2.4-A resolution to an R-factor of 18.7% and, good stereochemistry, explains many of the enzyme's unusual specificity, and functional properties. The overall fold is that of aspartate, aminotransferase and related B6 enzymes, but it also has specific, features. The structure of the complex with gabaculine, a substrate, analogue, shows unexpectedly that the substrate binding site involves, residues from the N-terminal domain of the molecule, notably Arg-32., Glu-406 is suitably positioned to repel alpha-carboxylic acids, thereby, suggesting a basis for ... [(full description)]
About this Structure
4GSA is a [Single protein] structure of sequence from [Synechococcus sp.] with PLP as [ligand]. Active as [Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [5.4.3.8]. Structure known Active Sites: COA and COB. Full crystallographic information is available from [OCA].
Reference
Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity., Hennig M, Grimm B, Contestabile R, John RA, Jansonius JN, Proc Natl Acad Sci U S A. 1997 May 13;94(10):4866-71. PMID:9144156
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