1g7p
From Proteopedia
(New page: 200px<br /><applet load="1g7p" size="450" color="white" frame="true" align="right" spinBox="true" caption="1g7p, resolution 1.50Å" /> '''CRYSTAL STRUCTURE OF...) |
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| - | [[Image:1g7p.gif|left|200px]]<br /><applet load="1g7p" size=" | + | [[Image:1g7p.gif|left|200px]]<br /><applet load="1g7p" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1g7p, resolution 1.50Å" /> | caption="1g7p, resolution 1.50Å" /> | ||
'''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE'''<br /> | '''CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of a non-standard peptide, YEA9, in complex with | + | The crystal structure of a non-standard peptide, YEA9, in complex with H-2Kb, at 1.5 A resolution demonstrates how YEA9 peptide can bind with surprisingly high affinity through insertion of alternative, long, non-canonical anchors into the B and E pockets. The use of "alternative pockets" represents a new mode of high affinity peptide binding, that should be considered when predicting peptide epitopes for MHC class I. These novel interactions encountered in this non-canonical high affinity peptide-MHC complex should help predict additional binding peptides from primary protein sequences and aid in the design of alternative approaches for peptide-based vaccines. |
==About this Structure== | ==About this Structure== | ||
| - | 1G7P is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] Full crystallographic information is available from [http:// | + | 1G7P is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Alpha-glucosidase Alpha-glucosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.20 3.2.1.20] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G7P OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Apostolopoulos, V.]] | [[Category: Apostolopoulos, V.]] | ||
| - | [[Category: Corper, A | + | [[Category: Corper, A L.]] |
[[Category: Li, W.]] | [[Category: Li, W.]] | ||
| - | [[Category: McKenzie, I | + | [[Category: McKenzie, I F.]] |
[[Category: Teyton, L.]] | [[Category: Teyton, L.]] | ||
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A.]] |
[[Category: Yu, M.]] | [[Category: Yu, M.]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: yeast]] | [[Category: yeast]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:47:01 2008'' |
Revision as of 10:47, 21 February 2008
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CRYSTAL STRUCTURE OF MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND YEAST ALPHA-GLUCOSIDASE
Overview
The crystal structure of a non-standard peptide, YEA9, in complex with H-2Kb, at 1.5 A resolution demonstrates how YEA9 peptide can bind with surprisingly high affinity through insertion of alternative, long, non-canonical anchors into the B and E pockets. The use of "alternative pockets" represents a new mode of high affinity peptide binding, that should be considered when predicting peptide epitopes for MHC class I. These novel interactions encountered in this non-canonical high affinity peptide-MHC complex should help predict additional binding peptides from primary protein sequences and aid in the design of alternative approaches for peptide-based vaccines.
About this Structure
1G7P is a Protein complex structure of sequences from Mus musculus with as ligand. Active as Alpha-glucosidase, with EC number 3.2.1.20 Full crystallographic information is available from OCA.
Reference
Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors., Apostolopoulos V, Yu M, Corper AL, Li W, McKenzie IF, Teyton L, Wilson IA, Plebanski M, J Mol Biol. 2002 May 17;318(5):1307-16. PMID:12083519
Page seeded by OCA on Thu Feb 21 12:47:01 2008
Categories: Alpha-glucosidase | Mus musculus | Protein complex | Apostolopoulos, V. | Corper, A L. | Li, W. | McKenzie, I F. | Teyton, L. | Wilson, I A. | Yu, M. | NAG | H-2kb | Mhc class i | S. cerevisiae | Yeast
