1oay
From Proteopedia
(New page: 200px<br /> <applet load="1oay" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oay, resolution 2.66Å" /> '''ANTIBODY MULTISPECI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OAY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]] with FUR as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OAY OCA]]. | + | 1OAY is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]] with FUR as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OAY OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: multispecificity]] | [[Category: multispecificity]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:54:10 2007'' |
Revision as of 10:49, 30 October 2007
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ANTIBODY MULTISPECIFICITY MEDIATED BY CONFORMATIONAL DIVERSITY
Overview
A single antibody was shown to adopt different binding-site conformations, and thereby bind unrelated antigens. Analysis by both x-ray, crystallography and pre-steady-state kinetics revealed an equilibrium, between different preexisting isomers, one of which possessed a, promiscuous, low-affinity binding site for aromatic ligands, including the, immunizing hapten. A subsequent induced-fit isomerization led to, high-affinity complexes with a deep and narrow binding site. A protein, antigen identified by repertoire selection made use of an unrelated, antibody isomer with a wide, shallow binding site. Conformational, diversity, whereby one sequence adopts multiple structures and multiple, functions, can increase the effective size of the antibody repertoire but, may also lead to autoimmunity ... [(full description)]
About this Structure
1OAY is a [Protein complex] structure of sequences from [Rattus rattus] with FUR as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298
Page seeded by OCA on Tue Oct 30 12:54:10 2007
