2oat
From Proteopedia
(New page: 200px<br /> <applet load="2oat" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oat, resolution 1.95Å" /> '''ORNITHINE AMINOTRAN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2OAT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PFM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2OAT OCA]]. | + | 2OAT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with PFM as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Ornithine_aminotransferase Ornithine aminotransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.13 2.6.1.13]]. Structure known Active Sites: FMA, FMB and FMC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2OAT OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine., Storici P, Capitani G, Muller R, Schirmer T, Jansonius JN, J Mol Biol. 1999 Jan 8;285(1):297-309. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9878407 9878407] | Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine., Storici P, Capitani G, Muller R, Schirmer T, Jansonius JN, J Mol Biol. 1999 Jan 8;285(1):297-309. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9878407 9878407] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Ornithine aminotransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Schirmer, T.]] | [[Category: Schirmer, T.]] | ||
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[[Category: pyridoxal phosphate]] | [[Category: pyridoxal phosphate]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:54:28 2007'' |
Revision as of 10:49, 30 October 2007
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ORNITHINE AMINOTRANSFERASE COMPLEXED WITH 5-FLUOROMETHYLORNITHINE
Overview
Ornithine aminotransferase (l-ornithine:2-oxoacid delta-aminotransferase;, EC 2.6.1.13), a pyridoxal-5'-phosphate-dependent mitochondrial enzyme, controls the l-ornithine level in tissues by catalyzing the transfer of, the delta-amino group of l-ornithine to 2-oxoglutarate, producing, l-glutamate- gamma-semialdehyde and l-glutamate. (2S, 5S)-5-Fluoromethylornithine is the only inhibitor exclusively specific for, ornithine aminotransferase known to date. Both in vitro and in vivo, it, blocks the enzyme by a suicide reaction leading to a covalent adduct with, the cofactor. The crystal structure of the enzyme-inhibitor complex was, solved at a resolution of 1.95 A. No significant conformational changes, compared with the native enzyme structure were observed. The structure, reveals the ... [(full description)]
About this Structure
2OAT is a [Single protein] structure of sequence from [Homo sapiens] with PFM as [ligand]. Active as [Ornithine aminotransferase], with EC number [2.6.1.13]. Structure known Active Sites: FMA, FMB and FMC. Full crystallographic information is available from [OCA].
Reference
Crystal structure of human ornithine aminotransferase complexed with the highly specific and potent inhibitor 5-fluoromethylornithine., Storici P, Capitani G, Muller R, Schirmer T, Jansonius JN, J Mol Biol. 1999 Jan 8;285(1):297-309. PMID:9878407
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