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1oar
From Proteopedia
(New page: 200px<br /> <applet load="1oar" size="450" color="white" frame="true" align="right" spinBox="true" caption="1oar, resolution 2.23Å" /> '''FV IGE SPE-7 IN COM...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1OAR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]] with CAC, NA, CL, DMS, EDO and AZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OAR OCA]]. | + | 1OAR is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]] with CAC, NA, CL, DMS, EDO and AZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OAR OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: multispecificity]] | [[Category: multispecificity]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:55:03 2007'' |
Revision as of 10:50, 30 October 2007
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FV IGE SPE-7 IN COMPLEX WITH ALIZARIN RED
Overview
A single antibody was shown to adopt different binding-site conformations, and thereby bind unrelated antigens. Analysis by both x-ray, crystallography and pre-steady-state kinetics revealed an equilibrium, between different preexisting isomers, one of which possessed a, promiscuous, low-affinity binding site for aromatic ligands, including the, immunizing hapten. A subsequent induced-fit isomerization led to, high-affinity complexes with a deep and narrow binding site. A protein, antigen identified by repertoire selection made use of an unrelated, antibody isomer with a wide, shallow binding site. Conformational, diversity, whereby one sequence adopts multiple structures and multiple, functions, can increase the effective size of the antibody repertoire but, may also lead to autoimmunity ... [(full description)]
About this Structure
1OAR is a [Single protein] structure of sequence from [Rattus rattus] with CAC, NA, CL, DMS, EDO and AZN as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Antibody multispecificity mediated by conformational diversity., James LC, Roversi P, Tawfik DS, Science. 2003 Feb 28;299(5611):1362-7. PMID:12610298
Page seeded by OCA on Tue Oct 30 12:55:03 2007
Categories: Rattus rattus | Single protein | James, L.C. | Roversi, P. | Tawfik, D. | AZN | CAC | CL | DMS | EDO | NA | Allergy | Antibody | Conformational diversity | Ige | Multispecificity
