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1w1w

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(New page: 200px<br /> <applet load="1w1w" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w1w, resolution 2.9&Aring;" /> '''SC SMC1HD:SCC1-C COM...)
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==About this Structure==
==About this Structure==
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1W1W is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with MG and ATG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W1W OCA]].
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1W1W is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with MG and ATG as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W1W OCA]].
==Reference==
==Reference==
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[[Category: mitosis]]
[[Category: mitosis]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 19:56:04 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:55:41 2007''

Revision as of 10:50, 30 October 2007

Image:1w1w.gif

1w1w, resolution 2.9Å

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SC SMC1HD:SCC1-C COMPLEX, ATPGS

Overview

A multisubunit complex called cohesin forms a huge ring structure that, mediates sister chromatid cohesion, possibly by entrapping sister DNAs, following replication. Cohesin's kleisin subunit Scc1 completes the ring, connecting the ABC-like ATPase heads of a V-shaped Smc1/3 heterodimer., Proteolytic cleavage of Scc1 by separase triggers sister chromatid, disjunction, presumably by breaking the Scc1 bridge. One half of the, SMC-kleisin bridge is revealed here by a crystal structure of Smc1's, ATPase complexed with Scc1's C-terminal domain. The latter forms a winged, helix that binds a pair of beta strands in Smc1's ATPase head. Mutation of, conserved residues within the contact interface destroys Scc1's, interaction with Smc1/3 heterodimers and eliminates cohesin function., Interaction of ... [(full description)]

About this Structure

1W1W is a [Protein complex] structure of sequences from [Saccharomyces cerevisiae] with MG and ATG as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure and stability of cohesin's Smc1-kleisin interaction., Haering CH, Schoffnegger D, Nishino T, Helmhart W, Nasmyth K, Lowe J, Mol Cell. 2004 Sep 24;15(6):951-64. PMID:15383284

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