2ixp
From Proteopedia
(New page: 200px<br /> <applet load="2ixp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ixp, resolution 2.80Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2IXP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with SO4, CL and SIN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IXP OCA]]. | + | 2IXP is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with SO4, CL and SIN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IXP OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: pp2a phosphatase activator prolyl isomerase ptpa]] | [[Category: pp2a phosphatase activator prolyl isomerase ptpa]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:57:29 2007'' |
Revision as of 10:52, 30 October 2007
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CRYSTAL STRUCTURE OF THE PP2A PHOSPHATASE ACTIVATOR YPA1 PTPA1 IN COMPLEX WITH MODEL SUBSTRATE
Overview
PTPA, an essential and specific activator of protein phosphatase 2A, (PP2A), functions as a peptidyl prolyl isomerase (PPIase). We present here, the crystal structures of human PTPA and of the two yeast orthologs (Ypa1, and Ypa2), revealing an all alpha-helical protein fold that is radically, different from other PPIases. The protein is organized into two domains, separated by a groove lined by highly conserved residues. To understand, the molecular mechanism of PTPA activity, Ypa1 was cocrystallized with a, proline-containing PPIase peptide substrate. In the complex, the peptide, binds at the interface of a peptide-induced dimer interface. Conserved, residues of the interdomain groove contribute to the peptide binding site, and dimer interface. Structure-guided mutational studies showed ... [(full description)]
About this Structure
2IXP is a [Single protein] structure of sequence from [Saccharomyces cerevisiae] with SO4, CL and SIN as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity., Leulliot N, Vicentini G, Jordens J, Quevillon-Cheruel S, Schiltz M, Barford D, van Tilbeurgh H, Goris J, Mol Cell. 2006 Aug 4;23(3):413-24. PMID:16885030
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