1k4r
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1K4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA]. | + | 1K4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Additional information on 1K4R is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb103_1.html Dengue Virus] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA]. |
==Reference== | ==Reference== | ||
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11893341 11893341] | Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11893341 11893341] | ||
| + | [[Category: Dengue Virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Tick-borne encephalitis virus]] | [[Category: Tick-borne encephalitis virus]] | ||
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[[Category: Icosahedral virus]] | [[Category: Icosahedral virus]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:45:07 2008'' |
Revision as of 07:45, 23 July 2008
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| 1k4r, resolution 24.00Å () | |||||||||
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| Related: | 1svb | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Structure of Dengue Virus
The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
About this Structure
1K4R is a Single protein structure of sequence from Tick-borne encephalitis virus. Additional information on 1K4R is available in a page on Dengue Virus at the RCSB PDB Molecule of the Month. Full crystallographic information is available from OCA.
Reference
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341
Page seeded by OCA on Wed Jul 23 10:45:07 2008
Categories: Dengue Virus | Single protein | Tick-borne encephalitis virus | Baker, T S. | Chipman, P R. | Corver, J. | Jones, C T. | Kuhn, R J. | Lenches, E. | Mukhopadhyay, S. | Pletnev, S V. | Rossmann, M G. | Strauss, E G. | Strauss, J H. | Zhang, W. | Dengue virus | Flaviviridae | Flavivirus | Glycoprotein e from tick-borne encephalitis virus | Icosahedral virus
