1hnw
From Proteopedia
(New page: 200px<br /><applet load="1hnw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hnw, resolution 3.40Å" /> '''STRUCTURE OF THE THE...) |
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| - | [[Image:1hnw.gif|left|200px]]<br /><applet load="1hnw" size=" | + | [[Image:1hnw.gif|left|200px]]<br /><applet load="1hnw" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1hnw, resolution 3.40Å" /> | caption="1hnw, resolution 3.40Å" /> | ||
'''STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE'''<br /> | '''STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE'''<br /> | ||
==Overview== | ==Overview== | ||
| - | We have used the recently determined atomic structure of the 30S ribosomal | + | We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function. |
==About this Structure== | ==About this Structure== | ||
| - | 1HNW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with MG, ZN and TAC as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1HNW is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=TAC:'>TAC</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNW OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thermus thermophilus]] | [[Category: Thermus thermophilus]] | ||
| - | [[Category: Brodersen, D | + | [[Category: Brodersen, D E.]] |
| - | [[Category: Carter, A | + | [[Category: Carter, A P.]] |
| - | [[Category: Jr., W | + | [[Category: Jr., W M.Clemons.]] |
[[Category: Morgan-Warren, R.]] | [[Category: Morgan-Warren, R.]] | ||
[[Category: Ramakrishnan, V.]] | [[Category: Ramakrishnan, V.]] | ||
| - | [[Category: Wimberly, B | + | [[Category: Wimberly, B T.]] |
[[Category: MG]] | [[Category: MG]] | ||
[[Category: TAC]] | [[Category: TAC]] | ||
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[[Category: tetracycline]] | [[Category: tetracycline]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:03:18 2008'' |
Revision as of 11:03, 21 February 2008
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STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE
Overview
We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.
About this Structure
1HNW is a Protein complex structure of sequences from Thermus thermophilus with , and as ligands. Full crystallographic information is available from OCA.
Reference
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit., Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V, Cell. 2000 Dec 22;103(7):1143-54. PMID:11163189
Page seeded by OCA on Thu Feb 21 13:03:18 2008
