2ix4
From Proteopedia
(New page: 200px<br /> <applet load="2ix4" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ix4, resolution 1.95Å" /> '''ARABIDOPSIS THALIAN...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2IX4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with K and 6NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IX4 OCA]]. | + | 2IX4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]] with K and 6NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41]]. Structure known Active Site: ACA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IX4 OCA]]. |
==Reference== | ==Reference== | ||
Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase., Christensen CE, Kragelund BB, von Wettstein-Knowles P, Henriksen A, Protein Sci. 2007 Feb;16(2):261-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17242430 17242430] | Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase., Christensen CE, Kragelund BB, von Wettstein-Knowles P, Henriksen A, Protein Sci. 2007 Feb;16(2):261-72. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17242430 17242430] | ||
[[Category: Arabidopsis thaliana]] | [[Category: Arabidopsis thaliana]] | ||
| + | [[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Christensen, C.E.]] | [[Category: Christensen, C.E.]] | ||
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[[Category: transit peptide]] | [[Category: transit peptide]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:57:54 2007'' |
Revision as of 10:53, 30 October 2007
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ARABIDOPSIS THALIANA MITOCHONDRIAL BETA-KETOACYL ACP SYNTHASE HEXANOIC ACID COMPLEX
Overview
Two distinct ways of organizing fatty acid biosynthesis exist: the, multifunctional type I fatty acid synthase (FAS) of mammals, fungi, and, lower eukaryotes with activities residing on one or two polypeptides; and, the dissociated type II FAS of prokaryotes, plastids, and mitochondria, with individual activities encoded by discrete genes. The beta-ketoacyl, [ACP] synthase (KAS) moiety of the mitochondrial FAS (mtKAS) is targeted, by the antibiotic cerulenin and possibly by the other antibiotics, inhibiting prokaryotic KASes: thiolactomycin, platensimycin, and the, alpha-methylene butyrolactone, C75. The high degree of structural, similarity between mitochondrial and prokaryotic KASes complicates, development of novel antibiotics targeting prokaryotic KAS without, affecting KAS domains of ... [(full description)]
About this Structure
2IX4 is a [Single protein] structure of sequence from [Arabidopsis thaliana] with K and 6NA as [ligands]. Active as [Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [2.3.1.41]. Structure known Active Site: ACA. Full crystallographic information is available from [OCA].
Reference
Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase., Christensen CE, Kragelund BB, von Wettstein-Knowles P, Henriksen A, Protein Sci. 2007 Feb;16(2):261-72. PMID:17242430
Page seeded by OCA on Tue Oct 30 12:57:54 2007
Categories: Arabidopsis thaliana | Beta-ketoacyl-acyl-carrier-protein synthase I | Single protein | Christensen, C.E. | Henriksen, A. | Kragelund, B. | Wettstein-Knowles, P.Von. | 6NA | K | Acyl complex | Acyltransferase | Beta-ketoacyl-(acyl carrier protein) synthase | Condensing enzyme | Fatty acid biosynthesis | Fatty acid elongation | Lipid metabolism | Lipid synthesis | Mitochondrion | Synthase | Transferase | Transit peptide
