1huu
From Proteopedia
(New page: 200px<br /><applet load="1huu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1huu, resolution 2.0Å" /> '''DNA-BINDING PROTEIN H...) |
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| - | [[Image:1huu.jpg|left|200px]]<br /><applet load="1huu" size=" | + | [[Image:1huu.jpg|left|200px]]<br /><applet load="1huu" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1huu, resolution 2.0Å" /> | caption="1huu, resolution 2.0Å" /> | ||
'''DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS'''<br /> | '''DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The prokaryotic protein HU, integration host factor (IHF) from Escherichia | + | The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions. |
==About this Structure== | ==About this Structure== | ||
| - | 1HUU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http:// | + | 1HUU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HUU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Appelt, K.]] | [[Category: Appelt, K.]] | ||
[[Category: Tanaka, I.]] | [[Category: Tanaka, I.]] | ||
| - | [[Category: White, S | + | [[Category: White, S W.]] |
| - | [[Category: Wilson, K | + | [[Category: Wilson, K S.]] |
[[Category: alpha/beta class]] | [[Category: alpha/beta class]] | ||
[[Category: dna supercoiling]] | [[Category: dna supercoiling]] | ||
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[[Category: minor groove binder]] | [[Category: minor groove binder]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:05:04 2008'' |
Revision as of 11:05, 21 February 2008
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DNA-BINDING PROTEIN HU FROM BACILLUS STEAROTHERMOPHILUS
Overview
The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.
About this Structure
1HUU is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
A protein structural motif that bends DNA., White SW, Appelt K, Wilson KS, Tanaka I, Proteins. 1989;5(4):281-8. PMID:2508086
Page seeded by OCA on Thu Feb 21 13:05:04 2008
