1bq6
From Proteopedia
(New page: 200px<br /> <applet load="1bq6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bq6, resolution 1.56Å" /> '''CHALCONE SYNTHASE F...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BQ6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]] with SO4 and COA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.74 2.3.1.74]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BQ6 OCA]]. | + | 1BQ6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Medicago_sativa Medicago sativa]] with SO4 and COA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Naringenin-chalcone_synthase Naringenin-chalcone synthase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.74 2.3.1.74]]. Structure known Active Site: CYS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BQ6 OCA]]. |
==Reference== | ==Reference== | ||
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis., Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP, Nat Struct Biol. 1999 Aug;6(8):775-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10426957 10426957] | Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis., Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP, Nat Struct Biol. 1999 Aug;6(8):775-84. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10426957 10426957] | ||
[[Category: Medicago sativa]] | [[Category: Medicago sativa]] | ||
| + | [[Category: Naringenin-chalcone synthase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bowman, M.E.]] | [[Category: Bowman, M.E.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:58:41 2007'' |
Revision as of 10:53, 30 October 2007
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CHALCONE SYNTHASE FROM ALFALFA WITH COENZYME A
Overview
Chalcone synthase (CHS) is pivotal for the biosynthesis of flavonoid, antimicrobial phytoalexins and anthocyanin pigments in plants. It produces, chalcone by condensing one p-coumaroyl- and three malonyl-coenzyme A, thioesters into a polyketide reaction intermediate that cyclizes. The, crystal structures of CHS alone and complexed with substrate and product, analogs reveal the active site architecture that defines the sequence and, chemistry of multiple decarboxylation and condensation reactions and, provides a molecular understanding of the cyclization reaction leading to, chalcone synthesis. The structure of CHS complexed with resveratrol also, suggests how stilbene synthase, a related enzyme, uses the same substrates, and an alternate cyclization pathway to form resveratrol. By using ... [(full description)]
About this Structure
1BQ6 is a [Single protein] structure of sequence from [Medicago sativa] with SO4 and COA as [ligands]. Active as [Naringenin-chalcone synthase], with EC number [2.3.1.74]. Structure known Active Site: CYS. Full crystallographic information is available from [OCA].
Reference
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis., Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP, Nat Struct Biol. 1999 Aug;6(8):775-84. PMID:10426957
Page seeded by OCA on Tue Oct 30 12:58:41 2007
