1i30
From Proteopedia
(New page: 200px<br /><applet load="1i30" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i30, resolution 2.4Å" /> '''E. COLI ENOYL REDUCTA...) |
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| - | [[Image:1i30.gif|left|200px]]<br /><applet load="1i30" size=" | + | [[Image:1i30.gif|left|200px]]<br /><applet load="1i30" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1i30, resolution 2.4Å" /> | caption="1i30, resolution 2.4Å" /> | ||
'''E. COLI ENOYL REDUCTASE +NAD+SB385826'''<br /> | '''E. COLI ENOYL REDUCTASE +NAD+SB385826'''<br /> | ||
==Overview== | ==Overview== | ||
| - | 1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and | + | 1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI. |
==About this Structure== | ==About this Structure== | ||
| - | 1I30 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NAD and 826 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http:// | + | 1I30 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=NAD:'>NAD</scene> and <scene name='pdbligand=826:'>826</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I30 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Janson, C | + | [[Category: Janson, C A.]] |
| - | [[Category: Miller, W | + | [[Category: Miller, W H.]] |
| - | [[Category: Payne, D | + | [[Category: Payne, D J.]] |
[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
| - | [[Category: Seefeld, M | + | [[Category: Seefeld, M A.]] |
[[Category: 826]] | [[Category: 826]] | ||
[[Category: NAD]] | [[Category: NAD]] | ||
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[[Category: enoyl reductase]] | [[Category: enoyl reductase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:07:25 2008'' |
Revision as of 11:07, 21 February 2008
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E. COLI ENOYL REDUCTASE +NAD+SB385826
Overview
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.
About this Structure
1I30 is a Single protein structure of sequence from Escherichia coli with and as ligands. Active as [acyl-carrier-protein_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number 1.3.1.9 Full crystallographic information is available from OCA.
Reference
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI)., Heerding DA, Chan G, DeWolf WE, Fosberry AP, Janson CA, Jaworski DD, McManus E, Miller WH, Moore TD, Payne DJ, Qiu X, Rittenhouse SF, Slater-Radosti C, Smith W, Takata DT, Vaidya KS, Yuan CC, Huffman WF, Bioorg Med Chem Lett. 2001 Aug 20;11(16):2061-5. PMID:11514139 [[Category: Enoyl-[acyl-carrier-protein] reductase (NADH)]]
Page seeded by OCA on Thu Feb 21 13:07:25 2008
Categories: Escherichia coli | Single protein | Janson, C A. | Miller, W H. | Payne, D J. | Qiu, X. | Seefeld, M A. | 826 | NAD | Acp | Antibiotic | Enoyl reductase
