1i7x
From Proteopedia
(New page: 200px<br /><applet load="1i7x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i7x, resolution 3.00Å" /> '''BETA-CATENIN/E-CADHE...) |
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| - | [[Image:1i7x.gif|left|200px]]<br /><applet load="1i7x" size=" | + | [[Image:1i7x.gif|left|200px]]<br /><applet load="1i7x" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1i7x, resolution 3.00Å" /> | caption="1i7x, resolution 3.00Å" /> | ||
'''BETA-CATENIN/E-CADHERIN COMPLEX'''<br /> | '''BETA-CATENIN/E-CADHERIN COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
| - | As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the | + | As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly. |
==About this Structure== | ==About this Structure== | ||
| - | 1I7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1I7X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I7X OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Huber, A | + | [[Category: Huber, A H.]] |
| - | [[Category: Weis, W | + | [[Category: Weis, W I.]] |
[[Category: armadillo repeat]] | [[Category: armadillo repeat]] | ||
[[Category: beta-catenin]] | [[Category: beta-catenin]] | ||
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[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:08:57 2008'' |
Revision as of 11:08, 21 February 2008
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BETA-CATENIN/E-CADHERIN COMPLEX
Overview
As a component of adherens junctions and the Wnt signaling pathway, beta-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC. We have determined the crystal structures of both unphosphorylated and phosphorylated E-cadherin cytoplasmic domain complexed with the arm repeat region of beta-catenin. The interaction spans all 12 arm repeats, and features quasi-independent binding regions that include helices which interact with both ends of the arm repeat domain and an extended stretch of 14 residues which closely resembles a portion of XTcf-3. Phosphorylation of E-cadherin results in interactions with a hydrophobic patch of beta-catenin that mimics the binding of an amphipathic XTcf-3 helix. APC contains sequences homologous to the phosphorylated region of cadherin, and is likely to bind similarly.
About this Structure
1I7X is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin., Huber AH, Weis WI, Cell. 2001 May 4;105(3):391-402. PMID:11348595
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