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1m0g
From Proteopedia
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| - | + | ==Solution structure of the alpha domain of mt_nc== | |
| - | [[ | + | <StructureSection load='1m0g' size='340' side='right' caption='[[1m0g]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1m0g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Notothenia_coriiceps Notothenia coriiceps]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M0G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M0G FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m0j|1m0j]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m0g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m0g RCSB], [http://www.ebi.ac.uk/pdbsum/1m0g PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of an N-terminal beta domain with 9 cysteines and 3 metal ions and a carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The position of the ninth Cys of the alpha domain of MT_nc is different from the corresponding Cys of mammalian MTs. As a result, the last CXCC motif in the mammalian MT sequence becomes CXXXCC in the fish MT. This difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in mammalian metallothioneins. | ||
| - | + | Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps.,Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA Structure. 2003 Apr;11(4):435-43. PMID:12679021<ref>PMID:12679021</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | < | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | == | + | |
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[[Category: Notothenia coriiceps]] | [[Category: Notothenia coriiceps]] | ||
| - | [[Category: Single protein]] | ||
[[Category: Capasso, C.]] | [[Category: Capasso, C.]] | ||
[[Category: Carginale, V.]] | [[Category: Carginale, V.]] | ||
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[[Category: Temussi, P A.]] | [[Category: Temussi, P A.]] | ||
[[Category: Cadmium-thiolate cluster]] | [[Category: Cadmium-thiolate cluster]] | ||
| - | + | [[Category: Metal binding protein]] | |
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Revision as of 05:44, 8 June 2014
Solution structure of the alpha domain of mt_nc
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