2byp
From Proteopedia
(New page: 200px<br /> <applet load="2byp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2byp, resolution 2.07Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BYP is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]] with NAG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BYP OCA]]. | + | 2BYP is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica]] with NAG as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BYP OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: nicotinic acetylcholine receptor complex]] | [[Category: nicotinic acetylcholine receptor complex]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:01:40 2007'' |
Revision as of 10:56, 30 October 2007
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CRYSTAL STRUCTURE OF APLYSIA CALIFORNICA ACHBP IN COMPLEX WITH ALPHA-CONOTOXIN IMI
Overview
Upon ligand binding at the subunit interfaces, the extracellular domain of, the nicotinic acetylcholine receptor undergoes conformational changes, and, agonist binding allosterically triggers opening of the ion channel. The, soluble acetylcholine-binding protein (AChBP) from snail has been shown to, be a structural and functional surrogate of the ligand-binding domain, (LBD) of the receptor. Yet, individual AChBP species display disparate, affinities for nicotinic ligands. The crystal structure of AChBP from, Aplysia californica in the apo form reveals a more open loop C and, distinctive positions for other surface loops, compared with previous, structures. Analysis of Aplysia AChBP complexes with nicotinic ligands, shows that loop C, which does not significantly change conformation upon, ... [(full description)]
About this Structure
2BYP is a [Protein complex] structure of sequences from [Aplysia californica] with NAG as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations., Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, Bourne Y, EMBO J. 2005 Oct 19;24(20):3635-46. Epub 2005 Sep 29. PMID:16193063
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