2bv3
From Proteopedia
(New page: 200px<br /> <applet load="2bv3" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bv3, resolution 2.50Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BV3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]] with MG and GNP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BV3 OCA]]. | + | 2BV3 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]] with MG and GNP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BV3 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: translation mutation thr84ala]] | [[Category: translation mutation thr84ala]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:02:59 2007'' |
Revision as of 10:58, 30 October 2007
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CRYSTAL STRUCTURE OF A MUTANT ELONGATION FACTOR G TRAPPED WITH A GTP ANALOGUE
Overview
Elongation factor G (EF-G) is a G protein factor that catalyzes the, translocation step in protein synthesis on the ribosome. Its GTP, conformation in the absence of the ribosome is currently unknown. We, present the structure of a mutant EF-G (T84A) in complex with the, non-hydrolysable GTP analogue GDPNP. The crystal structure provides a, first insight into conformational changes induced in EF-G by GTP., Comparison of this structure with that of EF-G in complex with GDP, suggests that the GTP and GDP conformations in solution are very similar, and that the major contribution to the active GTPase conformation, which, is quite different, therefore comes from its interaction with the, ribosome.
About this Structure
2BV3 is a [Single protein] structure of sequence from [Thermus thermophilus] with MG and GNP as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a mutant elongation factor G trapped with a GTP analogue., Hansson S, Singh R, Gudkov AT, Liljas A, Logan DT, FEBS Lett. 2005 Aug 15;579(20):4492-7. PMID:16083884
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