3d20

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==About this Structure==
==About this Structure==
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3D20 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D20 OCA].
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3D20 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D20 OCA].
==Reference==
==Reference==
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Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir., Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT, J Mol Biol. 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18597780 18597780]
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<ref group="xtra">PMID:18597780</ref><ref group="xtra">PMID:16962136</ref><ref group="xtra">PMID:16277992</ref><references group="xtra"/>
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Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114., Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT, J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16962136 16962136]
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Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S., Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT, J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16277992 16277992]
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[[Category: HIV-1 retropepsin]]
[[Category: HIV-1 retropepsin]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
 
[[Category: Ghosh, A K.]]
[[Category: Ghosh, A K.]]
[[Category: Harrison, R W.]]
[[Category: Harrison, R W.]]
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[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 16 08:56:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:35:37 2009''

Revision as of 16:35, 17 February 2009

Image:3d20.png

Template:STRUCTURE 3d20

Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA

Template:ABSTRACT PUBMED 18597780

About this Structure

3D20 is a 2 chains structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

  • Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. J Mol Biol. 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1. PMID:18597780 doi:10.1016/j.jmb.2008.05.062
  • Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:16962136 doi:10.1016/j.jmb.2006.08.007
  • Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095

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