2c91
From Proteopedia
(New page: 200px<br /> <applet load="2c91" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c91, resolution 2.30Å" /> '''MOUSE SUCCINIC SEMI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C91 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with PO4, NAP, TLA, MES and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C91 OCA]]. | + | 2C91 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with PO4, NAP, TLA, MES and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C91 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: tartrate]] | [[Category: tartrate]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:04:28 2007'' |
Revision as of 10:59, 30 October 2007
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MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5
Overview
The aldo-keto reductases make up a superfamily of enzymes which can reduce, a variety of aldehydes and ketones to their corresponding alcohols. Within, each family are distinct preferences for certain substrates, presumably, reflecting their role within the cell. The original member of the AKR7A, subfamily was purified from liver as an aflatoxin dialdehyde reductase, AKR7A1. However, recent additions to the family have revealed that even, closely related enzymes have clear substrate preferences with AKR7A2, AKR7A4, and AKR7A5 showing much higher affinities for succinic, semialdehyde (SSA) than does AKR7A1. To investigate the structural basis, of this specificity, the crystal structure of mouse AKR7A5 has been, determined to better than 2.5 A resolution. The structure is of the, ternary ... [(full description)]
About this Structure
2C91 is a [Single protein] structure of sequence from [Mus musculus] with PO4, NAP, TLA, MES and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity., Zhu X, Lapthorn AJ, Ellis EM, Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003
Page seeded by OCA on Tue Oct 30 13:04:28 2007
Categories: Mus musculus | Single protein | Ellis, E.M. | Lapthorn, A.J. | Zhu, X. | GOL | MES | NAP | PO4 | TLA | Akr | Aldo/keto reductase | Golgi stack | Nad | Nadp | Oxidoreductase | Succinic semialdehyde reductase | Tartrate
