This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1jsy
From Proteopedia
(New page: 200px<br /><applet load="1jsy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jsy, resolution 2.9Å" /> '''Crystal structure of ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1jsy.gif|left|200px]]<br /><applet load="1jsy" size=" | + | [[Image:1jsy.gif|left|200px]]<br /><applet load="1jsy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jsy, resolution 2.9Å" /> | caption="1jsy, resolution 2.9Å" /> | ||
'''Crystal structure of bovine arrestin-2'''<br /> | '''Crystal structure of bovine arrestin-2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Arrestin binding to activated, phosphorylated G protein-coupled receptors | + | Arrestin binding to activated, phosphorylated G protein-coupled receptors (GPCRs) represents a critical step in regulation of light- and hormone-dependent signaling. Nonvisual arrestins, such as arrestin-2, interact with multiple proteins for the purpose of propagating and terminating signaling events. Using a combination of X-ray crystallography, molecular modeling, mutagenesis, and binding analysis, we reveal structural features of arrestin-2 that may enable simultaneous binding to phosphorylated receptor, SH3 domains, phosphoinositides, and beta-adaptin. The structure of full-length arrestin-2 thus provides a uniquely oriented scaffold for assembly of multiple, diverse molecules involved in GPCR signal transduction. |
==About this Structure== | ==About this Structure== | ||
| - | 1JSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http:// | + | 1JSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSY OCA]. |
==Reference== | ==Reference== | ||
| Line 13: | Line 13: | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Benovic, J | + | [[Category: Benovic, J L.]] |
[[Category: Brenner, C.]] | [[Category: Brenner, C.]] | ||
| - | [[Category: Kim, Y | + | [[Category: Kim, Y M.]] |
| - | [[Category: Milano, S | + | [[Category: Milano, S K.]] |
| - | [[Category: Pace, H | + | [[Category: Pace, H C.]] |
[[Category: beta-arrestins]] | [[Category: beta-arrestins]] | ||
[[Category: desensitization]] | [[Category: desensitization]] | ||
| Line 24: | Line 24: | ||
[[Category: nonvisual arrestins]] | [[Category: nonvisual arrestins]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:26:21 2008'' |
Revision as of 11:26, 21 February 2008
|
Crystal structure of bovine arrestin-2
Overview
Arrestin binding to activated, phosphorylated G protein-coupled receptors (GPCRs) represents a critical step in regulation of light- and hormone-dependent signaling. Nonvisual arrestins, such as arrestin-2, interact with multiple proteins for the purpose of propagating and terminating signaling events. Using a combination of X-ray crystallography, molecular modeling, mutagenesis, and binding analysis, we reveal structural features of arrestin-2 that may enable simultaneous binding to phosphorylated receptor, SH3 domains, phosphoinositides, and beta-adaptin. The structure of full-length arrestin-2 thus provides a uniquely oriented scaffold for assembly of multiple, diverse molecules involved in GPCR signal transduction.
About this Structure
1JSY is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis., Milano SK, Pace HC, Kim YM, Brenner C, Benovic JL, Biochemistry. 2002 Mar 12;41(10):3321-8. PMID:11876640
Page seeded by OCA on Thu Feb 21 13:26:21 2008
