1jsy
From Proteopedia
(New page: 200px<br /><applet load="1jsy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jsy, resolution 2.9Å" /> '''Crystal structure of ...) |
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| - | [[Image:1jsy.gif|left|200px]]<br /><applet load="1jsy" size=" | + | [[Image:1jsy.gif|left|200px]]<br /><applet load="1jsy" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1jsy, resolution 2.9Å" /> | caption="1jsy, resolution 2.9Å" /> | ||
'''Crystal structure of bovine arrestin-2'''<br /> | '''Crystal structure of bovine arrestin-2'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Arrestin binding to activated, phosphorylated G protein-coupled receptors | + | Arrestin binding to activated, phosphorylated G protein-coupled receptors (GPCRs) represents a critical step in regulation of light- and hormone-dependent signaling. Nonvisual arrestins, such as arrestin-2, interact with multiple proteins for the purpose of propagating and terminating signaling events. Using a combination of X-ray crystallography, molecular modeling, mutagenesis, and binding analysis, we reveal structural features of arrestin-2 that may enable simultaneous binding to phosphorylated receptor, SH3 domains, phosphoinositides, and beta-adaptin. The structure of full-length arrestin-2 thus provides a uniquely oriented scaffold for assembly of multiple, diverse molecules involved in GPCR signal transduction. |
==About this Structure== | ==About this Structure== | ||
| - | 1JSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http:// | + | 1JSY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Benovic, J | + | [[Category: Benovic, J L.]] |
[[Category: Brenner, C.]] | [[Category: Brenner, C.]] | ||
| - | [[Category: Kim, Y | + | [[Category: Kim, Y M.]] |
| - | [[Category: Milano, S | + | [[Category: Milano, S K.]] |
| - | [[Category: Pace, H | + | [[Category: Pace, H C.]] |
[[Category: beta-arrestins]] | [[Category: beta-arrestins]] | ||
[[Category: desensitization]] | [[Category: desensitization]] | ||
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[[Category: nonvisual arrestins]] | [[Category: nonvisual arrestins]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:26:21 2008'' |
Revision as of 11:26, 21 February 2008
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Crystal structure of bovine arrestin-2
Overview
Arrestin binding to activated, phosphorylated G protein-coupled receptors (GPCRs) represents a critical step in regulation of light- and hormone-dependent signaling. Nonvisual arrestins, such as arrestin-2, interact with multiple proteins for the purpose of propagating and terminating signaling events. Using a combination of X-ray crystallography, molecular modeling, mutagenesis, and binding analysis, we reveal structural features of arrestin-2 that may enable simultaneous binding to phosphorylated receptor, SH3 domains, phosphoinositides, and beta-adaptin. The structure of full-length arrestin-2 thus provides a uniquely oriented scaffold for assembly of multiple, diverse molecules involved in GPCR signal transduction.
About this Structure
1JSY is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Scaffolding functions of arrestin-2 revealed by crystal structure and mutagenesis., Milano SK, Pace HC, Kim YM, Brenner C, Benovic JL, Biochemistry. 2002 Mar 12;41(10):3321-8. PMID:11876640
Page seeded by OCA on Thu Feb 21 13:26:21 2008
