1k4r
From Proteopedia
(New page: 200px<br /><applet load="1k4r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k4r, resolution 24.Å" /> '''Structure of Dengue V...) |
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| - | [[Image:1k4r.gif|left|200px]]<br /><applet load="1k4r" size=" | + | [[Image:1k4r.gif|left|200px]]<br /><applet load="1k4r" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1k4r, resolution 24.Å" /> | caption="1k4r, resolution 24.Å" /> | ||
'''Structure of Dengue Virus'''<br /> | '''Structure of Dengue Virus'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The first structure of a flavivirus has been determined by using a | + | The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane. |
==About this Structure== | ==About this Structure== | ||
| - | 1K4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http:// | + | 1K4R is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Tick-borne_encephalitis_virus Tick-borne encephalitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K4R OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Tick-borne encephalitis virus]] | [[Category: Tick-borne encephalitis virus]] | ||
| - | [[Category: Baker, T | + | [[Category: Baker, T S.]] |
| - | [[Category: Chipman, P | + | [[Category: Chipman, P R.]] |
[[Category: Corver, J.]] | [[Category: Corver, J.]] | ||
| - | [[Category: Jones, C | + | [[Category: Jones, C T.]] |
| - | [[Category: Kuhn, R | + | [[Category: Kuhn, R J.]] |
[[Category: Lenches, E.]] | [[Category: Lenches, E.]] | ||
[[Category: Mukhopadhyay, S.]] | [[Category: Mukhopadhyay, S.]] | ||
| - | [[Category: Pletnev, S | + | [[Category: Pletnev, S V.]] |
| - | [[Category: Rossmann, M | + | [[Category: Rossmann, M G.]] |
| - | [[Category: Strauss, E | + | [[Category: Strauss, E G.]] |
| - | [[Category: Strauss, J | + | [[Category: Strauss, J H.]] |
[[Category: Zhang, W.]] | [[Category: Zhang, W.]] | ||
[[Category: dengue virus]] | [[Category: dengue virus]] | ||
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[[Category: icosahedral virus]] | [[Category: icosahedral virus]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:30:14 2008'' |
Revision as of 11:30, 21 February 2008
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Structure of Dengue Virus
Overview
The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.
About this Structure
1K4R is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.
Reference
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341
Page seeded by OCA on Thu Feb 21 13:30:14 2008
Categories: Single protein | Tick-borne encephalitis virus | Baker, T S. | Chipman, P R. | Corver, J. | Jones, C T. | Kuhn, R J. | Lenches, E. | Mukhopadhyay, S. | Pletnev, S V. | Rossmann, M G. | Strauss, E G. | Strauss, J H. | Zhang, W. | Dengue virus | Flaviviridae | Flavivirus | Glycoprotein e from tick-borne encephalitis virus | Icosahedral virus
