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2oah

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==About this Structure==
==About this Structure==
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2OAH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAH OCA].
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2OAH is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OAH OCA].
==Reference==
==Reference==
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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation., Stauffer SR, Stanton MG, Gregro AR, Steinbeiser MA, Shaffer JR, Nantermet PG, Barrow JC, Rittle KE, Collusi D, Espeseth AS, Lai MT, Pietrak BL, Holloway MK, McGaughey GB, Munshi SK, Hochman JH, Simon AJ, Selnick HG, Graham SL, Vacca JP, Bioorg Med Chem Lett. 2007 Mar 15;17(6):1788-92. Epub 2006 Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17257835 17257835]
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<ref group="xtra">PMID:17257835</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
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[[Category: Single protein]]
 
[[Category: Munshi, S.]]
[[Category: Munshi, S.]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:24:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:03:52 2009''

Revision as of 11:03, 16 February 2009

Image:2oah.png

Template:STRUCTURE 2oah

Crystal Structure of Human Beta Secretase Complexed with inhibitor

Template:ABSTRACT PUBMED 17257835

About this Structure

2OAH is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Stauffer SR, Stanton MG, Gregro AR, Steinbeiser MA, Shaffer JR, Nantermet PG, Barrow JC, Rittle KE, Collusi D, Espeseth AS, Lai MT, Pietrak BL, Holloway MK, McGaughey GB, Munshi SK, Hochman JH, Simon AJ, Selnick HG, Graham SL, Vacca JP. Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1788-92. Epub 2006 Dec 21. PMID:17257835 doi:10.1016/j.bmcl.2006.12.051

Page seeded by OCA on Mon Feb 16 13:03:52 2009

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