2cmz
From Proteopedia
(New page: 200px<br /> <applet load="2cmz" size="450" color="white" frame="true" align="right" spinBox="true" caption="2cmz, resolution 2.40Å" /> '''CRYSTAL STRUCTURE O...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CMZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]] with CA and PE4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CMZ OCA]]. | + | 2CMZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Vesicular_stomatitis_indiana_virus Vesicular stomatitis indiana virus]] with CA and PE4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CMZ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transmembrane]] | [[Category: transmembrane]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:08:38 2007'' |
Revision as of 11:03, 30 October 2007
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CRYSTAL STRUCTURE OF VSV-INDIANA (MUDD-SUMMERS STRAIN) GLYCOPROTEIN UNDER ITS ACIDIC CONFORMATION
Overview
The vesicular stomatitis virus has an atypical membrane fusion, glycoprotein (G) exhibiting a pH-dependent equilibrium between two forms, at the virus surface. Membrane fusion is triggered during the transition, from the high- to low-pH form. The structure of G in its low-pH form shows, the classic hairpin conformation observed in all other fusion proteins in, their postfusion conformation, in spite of a novel fold combining features, of fusion proteins from classes I and II. The structure provides a, framework for understanding the reversibility of the G conformational, change. Unexpectedly, G is homologous to gB of herpesviruses, which raises, important questions on viral evolution.
About this Structure
2CMZ is a [Single protein] structure of sequence from [Vesicular stomatitis indiana virus] with CA and PE4 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G., Roche S, Bressanelli S, Rey FA, Gaudin Y, Science. 2006 Jul 14;313(5784):187-91. PMID:16840692
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