2bj6

From Proteopedia

Revision as of 11:07, 30 October 2007

CRYSTAL STRUCTURE OF A DECAMERIC HNA-RNA HYBRID

Overview

The crystal structure of a decameric HNA/RNA (HNA =, 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the, RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid, duplex between a naturally occurring nucleic acid and a strand, which is, fully modified to contain a six-membered ring instead of ribose. The, presence of four duplex helices in the asymmetric unit allows for a, detailed discussion of hydration, which revealed a tighter spinelike, backbone hydration for the HNA- than for the RNA-strands. The reinforced, backbone hydration is suggested to contribute significantly to the, exceptional stability of HNA-containing duplexes and might be one of the, causes for the evolutionary preference for ribose-derived nucleic acids.

About this Structure

2BJ6 is a [Single protein] structure of sequence from [[1]] with SO4 as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid., Maier T, Przylas I, Strater N, Herdewijn P, Saenger W, J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130

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