1zp5

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==About this Structure==
==About this Structure==
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1ZP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].
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1ZP5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].
==Reference==
==Reference==
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N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8., Campestre C, Agamennone M, Tortorella P, Preziuso S, Biasone A, Gavuzzo E, Pochetti G, Mazza F, Hiller O, Tschesche H, Consalvi V, Gallina C, Bioorg Med Chem Lett. 2006 Jan 1;16(1):20-4. Epub 2005 Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16242329 16242329]
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<ref group="xtra">PMID:16242329</ref><ref group="xtra">PMID:12171558</ref><ref group="xtra">PMID:7577999</ref><ref group="xtra">PMID:11412979</ref><references group="xtra"/>
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Hydroxamic acids as pharmacological agents., Muri EM, Nieto MJ, Sindelar RD, Williamson JS, Curr Med Chem. 2002 Sep;9(17):1631-53. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12171558 12171558]
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Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor., Grams F, Crimmin M, Hinnes L, Huxley P, Pieper M, Tschesche H, Bode W, Biochemistry. 1995 Oct 31;34(43):14012-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7577999 7577999]
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Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors., Michaelides MR, Dellaria JF, Gong J, Holms JH, Bouska JJ, Stacey J, Wada CK, Heyman HR, Curtin ML, Guo Y, Goodfellow CL, Elmore IB, Albert DH, Magoc TJ, Marcotte PA, Morgan DW, Davidsen SK, Bioorg Med Chem Lett. 2001 Jun 18;11(12):1553-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11412979 11412979]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Neutrophil collagenase]]
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[[Category: Single protein]]
 
[[Category: Agamennone, M.]]
[[Category: Agamennone, M.]]
[[Category: Biasone, A.]]
[[Category: Biasone, A.]]
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:18:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:50:23 2009''

Revision as of 15:50, 16 February 2009

Image:1zp5.png

Template:STRUCTURE 1zp5

Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor

Template:ABSTRACT PUBMED 16242329

About this Structure

1ZP5 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Campestre C, Agamennone M, Tortorella P, Preziuso S, Biasone A, Gavuzzo E, Pochetti G, Mazza F, Hiller O, Tschesche H, Consalvi V, Gallina C. N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8. Bioorg Med Chem Lett. 2006 Jan 1;16(1):20-4. Epub 2005 Oct 18. PMID:16242329 doi:10.1016/j.bmcl.2005.09.057
  • Muri EM, Nieto MJ, Sindelar RD, Williamson JS. Hydroxamic acids as pharmacological agents. Curr Med Chem. 2002 Sep;9(17):1631-53. PMID:12171558
  • Grams F, Crimmin M, Hinnes L, Huxley P, Pieper M, Tschesche H, Bode W. Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor. Biochemistry. 1995 Oct 31;34(43):14012-20. PMID:7577999
  • Michaelides MR, Dellaria JF, Gong J, Holms JH, Bouska JJ, Stacey J, Wada CK, Heyman HR, Curtin ML, Guo Y, Goodfellow CL, Elmore IB, Albert DH, Magoc TJ, Marcotte PA, Morgan DW, Davidsen SK. Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1553-6. PMID:11412979

Page seeded by OCA on Mon Feb 16 17:50:23 2009

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