3hsc
From Proteopedia
(New page: 200px<br /><applet load="3hsc" size="450" color="white" frame="true" align="right" spinBox="true" caption="3hsc, resolution 1.93Å" /> '''THREE-DIMENSIONAL ST...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:3hsc.jpg|left|200px]]<br /><applet load="3hsc" size=" | + | [[Image:3hsc.jpg|left|200px]]<br /><applet load="3hsc" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="3hsc, resolution 1.93Å" /> | caption="3hsc, resolution 1.93Å" /> | ||
'''THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN'''<br /> | '''THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The three-dimensional structure of the amino-terminal 44K ATPase fragment | + | The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 3HSC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with MG, PO4, NA and ADP as [http://en.wikipedia.org/wiki/ligands ligands]. This structure | + | 3HSC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=ADP:'>ADP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure supersedes the now removed PDB entries 2HSC and 1HSC. Active as [http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSC OCA]. |
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Deluca-Flaherty, C | + | [[Category: Deluca-Flaherty, C R.]] |
| - | [[Category: Flaherty, K | + | [[Category: Flaherty, K M.]] |
| - | [[Category: Mckay, D | + | [[Category: Mckay, D B.]] |
[[Category: ADP]] | [[Category: ADP]] | ||
[[Category: MG]] | [[Category: MG]] | ||
| Line 23: | Line 23: | ||
[[Category: hydrolase (acting on acid anhydrides)]] | [[Category: hydrolase (acting on acid anhydrides)]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:09:53 2008'' |
Revision as of 17:09, 21 February 2008
|
THREE-DIMENSIONAL STRUCTURE OF THE ATPASE FRAGMENT OF A 70K HEAT-SHOCK COGNATE PROTEIN
Overview
The three-dimensional structure of the amino-terminal 44K ATPase fragment of the 70K bovine heat-shock cognate protein has been solved to a resolution of 2.2 A. The ATPase fragment has two structural lobes with a deep cleft between them; ATP binds at the base of the cleft. Surprisingly, the nucleotide-binding 'core' of the ATPase fragment has a tertiary structure similar to that of hexokinase, although the remainder of the structures of the two proteins are completely dissimilar, suggesting that both the phosphotransferase mechanism and the substrate-induced conformational change intrinsic to the hexokinases may be used by the 70K heat shock-related proteins.
About this Structure
3HSC is a Single protein structure of sequence from Bos taurus with , , and as ligands. This structure supersedes the now removed PDB entries 2HSC and 1HSC. Active as Adenosinetriphosphatase, with EC number 3.6.1.3 Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein., Flaherty KM, DeLuca-Flaherty C, McKay DB, Nature. 1990 Aug 16;346(6285):623-8. PMID:2143562
Page seeded by OCA on Thu Feb 21 19:09:53 2008
