1uxa
From Proteopedia
(New page: 200px<br /> <applet load="1uxa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1uxa, resolution 1.5Å" /> '''ADENOVIRUS AD37 FIBR...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1UXA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 1UXA is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Human_adenovirus_type_49 Human adenovirus type 49]] with ZN and ACT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UXA OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites., Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N, J Virol. 2004 Jul;78(14):7727-36. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15220447 15220447] | Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites., Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N, J Virol. 2004 Jul;78(14):7727-36. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15220447 15220447] | ||
| - | [[Category: Human adenovirus type | + | [[Category: Human adenovirus type 49]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Arnberg, N.]] | [[Category: Arnberg, N.]] | ||
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[[Category: sialic acid]] | [[Category: sialic acid]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:14:04 2007'' |
Revision as of 11:09, 30 October 2007
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ADENOVIRUS AD37 FIBRE HEAD IN COMPLEX WITH SIALYL-LACTOSE
Overview
Adenovirus serotype 37 (Ad37) belongs to species D and can cause epidemic, keratoconjunctivitis, whereas the closely related Ad19p does not. Primary, cell attachment by adenoviruses is mediated through receptor binding of, the knob domain of the fiber protein. The knobs of Ad37 and Ad19p differ, at only two positions, Lys240Glu and Asn340Asp. We report the, high-resolution crystal structures of the Ad37 and Ad19p knobs, both, native and in complex with sialic acid, which has been proposed as a, receptor for Ad37. Overall, the Ad37 and Ad19p knobs are very similar to, previously reported knob structures, especially to that of Ad5, which, binds the coxsackievirus-adenovirus receptor (CAR). Ad37 and Ad19p knobs, are structurally identical with the exception of the changed side chains, and ... [(full description)]
About this Structure
1UXA is a [Single protein] structure of sequence from [Human adenovirus type 49] with ZN and ACT as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites., Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N, J Virol. 2004 Jul;78(14):7727-36. PMID:15220447
Page seeded by OCA on Tue Oct 30 13:14:04 2007
Categories: Human adenovirus type 49 | Single protein | Arnberg, N. | Burmeister, W.P. | Cusack, S. | Guilligay, D. | Wadell, G. | ACT | ZN | Ad37 | Adenovirus | Cd46 | Conjunctivitis | Daf | Fibre | Neuraminic acid | Receptor | Sialic acid
