1l2g
From Proteopedia
(New page: 200px<br /><applet load="1l2g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l2g, resolution 2.85Å" /> '''Structure of a C-ter...) |
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| - | [[Image:1l2g.jpg|left|200px]]<br /><applet load="1l2g" size=" | + | [[Image:1l2g.jpg|left|200px]]<br /><applet load="1l2g" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1l2g, resolution 2.85Å" /> | caption="1l2g, resolution 2.85Å" /> | ||
'''Structure of a C-terminally truncated form of glycoprotein D from HSV-1'''<br /> | '''Structure of a C-terminally truncated form of glycoprotein D from HSV-1'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Herpes simplex virus (HSV) infection requires binding of the viral | + | Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites for another gD receptor, a 3-O-sulfonated heparan sulfate. Unexpectedly, the structures reveal a V-like immunoglobulin (Ig) fold at the core of gD that is closely related to cellular adhesion molecules and flanked by large N- and C-terminal extensions. The receptor binding segment of gD, an N-terminal hairpin, appears conformationally flexible, suggesting that a conformational change accompanying binding might be part of the viral entry mechanism. |
==About this Structure== | ==About this Structure== | ||
| - | 1L2G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1L2G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2G OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Carfi, A.]] | [[Category: Carfi, A.]] | ||
| - | [[Category: Cohen, G | + | [[Category: Cohen, G H.]] |
| - | [[Category: Eisenberg, R | + | [[Category: Eisenberg, R J.]] |
[[Category: Krummenacher, C.]] | [[Category: Krummenacher, C.]] | ||
| - | [[Category: Whitbeck, J | + | [[Category: Whitbeck, J C.]] |
| - | [[Category: Wiley, D | + | [[Category: Wiley, D C.]] |
| - | [[Category: Willis, S | + | [[Category: Willis, S H.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: ig fold]] | [[Category: ig fold]] | ||
[[Category: viral envelope glycoprotein]] | [[Category: viral envelope glycoprotein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:40:31 2008'' |
Revision as of 11:40, 21 February 2008
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Structure of a C-terminally truncated form of glycoprotein D from HSV-1
Overview
Herpes simplex virus (HSV) infection requires binding of the viral envelope glycoprotein D (gD) to cell surface receptors. We report the X-ray structures of a soluble, truncated ectodomain of gD both alone and in complex with the ectodomain of its cellular receptor HveA. Two bound anions suggest possible binding sites for another gD receptor, a 3-O-sulfonated heparan sulfate. Unexpectedly, the structures reveal a V-like immunoglobulin (Ig) fold at the core of gD that is closely related to cellular adhesion molecules and flanked by large N- and C-terminal extensions. The receptor binding segment of gD, an N-terminal hairpin, appears conformationally flexible, suggesting that a conformational change accompanying binding might be part of the viral entry mechanism.
About this Structure
1L2G is a Single protein structure of sequence from Human herpesvirus 4 with as ligand. Full crystallographic information is available from OCA.
Reference
Herpes simplex virus glycoprotein D bound to the human receptor HveA., Carfi A, Willis SH, Whitbeck JC, Krummenacher C, Cohen GH, Eisenberg RJ, Wiley DC, Mol Cell. 2001 Jul;8(1):169-79. PMID:11511370
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