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1tl8
From Proteopedia
(Difference between revisions)
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==About this Structure== | ==About this Structure== | ||
| - | 1TL8 is a | + | 1TL8 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TL8 OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:16033260</ref><references group="xtra"/> | |
[[Category: DNA topoisomerase]] | [[Category: DNA topoisomerase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Single protein]] | ||
[[Category: Antony, S.]] | [[Category: Antony, S.]] | ||
[[Category: Cushman, M.]] | [[Category: Cushman, M.]] | ||
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[[Category: Topoisomerase i]] | [[Category: Topoisomerase i]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 22:06:03 2009'' |
Revision as of 20:06, 16 February 2009
Contents |
Human DNA topoisomerase I (70 kDa) in complex with the indenoisoquinoline AI-III-52 and covalent complex with a 22 base pair DNA duplex
Template:ABSTRACT PUBMED 16033260
Disease
Known disease associated with this structure: DNA topoisomerase I, camptothecin-resistant OMIM:[126420]
About this Structure
1TL8 is a 4 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis. J Med Chem. 2005 Jul 28;48(15):4803-14. PMID:16033260 doi:10.1021/jm050076b
Page seeded by OCA on Mon Feb 16 22:06:03 2009
