1bx4
From Proteopedia
(New page: 200px<br /> <applet load="1bx4" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bx4, resolution 1.50Å" /> '''STRUCTURE OF HUMAN ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BX4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, MG and ADN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.20 2.7.1.20]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BX4 OCA]]. | + | 1BX4 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CL, MG and ADN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Adenosine_kinase Adenosine kinase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.20 2.7.1.20]]. Structure known Active Sites: ADA and ADB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BX4 OCA]]. |
==Reference== | ==Reference== | ||
Structure of human adenosine kinase at 1.5 A resolution., Mathews II, Erion MD, Ealick SE, Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9843365 9843365] | Structure of human adenosine kinase at 1.5 A resolution., Mathews II, Erion MD, Ealick SE, Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9843365 9843365] | ||
| + | [[Category: Adenosine kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: human adenosine kinase]] | [[Category: human adenosine kinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:15:58 2007'' |
Revision as of 11:11, 30 October 2007
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STRUCTURE OF HUMAN ADENOSINE KINASE AT 1.50 ANGSTROMS
Overview
Adenosine kinase (AK) is a key enzyme in the regulation of extracellular, adenosine and intracellular adenylate levels. Inhibitors of adenosine, kinase elevate adenosine to levels that activate nearby adenosine, receptors and produce a wide variety of therapeutically beneficial, activities. Accordingly, AK is a promising target for new analgesic, neuroprotective, and cardioprotective agents. We determined the structure, of human adenosine kinase by X-ray crystallography using MAD phasing, techniques and refined the structure to 1.5 A resolution. The enzyme, structure consisted of one large alpha/beta domain with nine beta-strands, eight alpha-helices, and one small alpha/beta-domain with five, beta-strands and two alpha-helices. The active site is formed along the, edge of the beta-sheet ... [(full description)]
About this Structure
1BX4 is a [Single protein] structure of sequence from [Homo sapiens] with CL, MG and ADN as [ligands]. Active as [Adenosine kinase], with EC number [2.7.1.20]. Structure known Active Sites: ADA and ADB. Full crystallographic information is available from [OCA].
Reference
Structure of human adenosine kinase at 1.5 A resolution., Mathews II, Erion MD, Ealick SE, Biochemistry. 1998 Nov 10;37(45):15607-20. PMID:9843365
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