1914
From Proteopedia
(New page: 200px<br /> <applet load="1914" size="450" color="white" frame="true" align="right" spinBox="true" caption="1914, resolution 2.53Å" /> '''SIGNAL RECOGNITION ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1914 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with PO4 and BME as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1914 OCA]]. | + | 1914 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with PO4 and BME as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: NUL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1914 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: translation regulation]] | [[Category: translation regulation]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:19:46 2007'' |
Revision as of 11:15, 30 October 2007
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SIGNAL RECOGNITION PARTICLE ALU RNA BINDING HETERODIMER, SRP9/14
Overview
The mammalian signal recognition particle (SRP) is an 11S cytoplasmic, ribonucleoprotein that plays an essential role in protein sorting. SRP, recognizes the signal sequence of the nascent polypeptide chain emerging, from the ribosome, and targets the ribosome-nascent chain-SRP complex to, the rough endoplasmic reticulum. The SRP consists of six polypeptides, (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide, RNA molecule. SRP9 and SRP14 proteins form a heterodimer that binds to the, Alu domain of SRP RNA which is responsible for translation arrest. We, report the first crystal structure of a mammalian SRP protein, that of the, mouse SRP9/14 heterodimer, determined at 2.5 A resolution. SRP9 and SRP14, are found to be structurally homologous, containing the same, ... [(full description)]
About this Structure
1914 is a [Single protein] structure of sequence from [Mus musculus] with PO4 and BME as [ligands]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].
Reference
The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14., Birse DE, Kapp U, Strub K, Cusack S, Aberg A, EMBO J. 1997 Jul 1;16(13):3757-66. PMID:9233785
Page seeded by OCA on Tue Oct 30 13:19:46 2007
