1mmj
From Proteopedia
(New page: 200px<br /><applet load="1mmj" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mmj, resolution 2.2Å" /> '''Porcine pancreatic el...) |
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| - | [[Image:1mmj.gif|left|200px]]<br /><applet load="1mmj" size=" | + | [[Image:1mmj.gif|left|200px]]<br /><applet load="1mmj" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1mmj, resolution 2.2Å" /> | caption="1mmj, resolution 2.2Å" /> | ||
'''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706'''<br /> | '''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of porcine pancreatic elastase (PPE) complexed with | + | The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors. |
==About this Structure== | ==About this Structure== | ||
| - | 1MMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SO4, CA and FR1 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http:// | + | 1MMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=FR1:'>FR1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMJ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: chymotrypsin family]] | [[Category: chymotrypsin family]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:56:41 2008'' |
Revision as of 11:56, 21 February 2008
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Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706
Overview
The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.
About this Structure
1MMJ is a Single protein structure of sequence from Sus scrofa with , and as ligands. Active as Pancreatic elastase, with EC number 3.4.21.36 Full crystallographic information is available from OCA.
Reference
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor., Kinoshita T, Nakanishi I, Sato A, Tada T, Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. PMID:12467609
Page seeded by OCA on Thu Feb 21 13:56:41 2008
