1mn8
From Proteopedia
(New page: 200px<br /><applet load="1mn8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mn8, resolution 1.0Å" /> '''Structure of Moloney ...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1mn8.gif|left|200px]]<br /><applet load="1mn8" size=" | + | [[Image:1mn8.gif|left|200px]]<br /><applet load="1mn8" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1mn8, resolution 1.0Å" /> | caption="1mn8, resolution 1.0Å" /> | ||
'''Structure of Moloney Murine Leukaemia Virus Matrix Protein'''<br /> | '''Structure of Moloney Murine Leukaemia Virus Matrix Protein'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Matrix proteins associated with the viral membrane are important in the | + | Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins. |
==About this Structure== | ==About this Structure== | ||
| - | 1MN8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full crystallographic information is available from [http:// | + | 1MN8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus Moloney murine leukemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MN8 OCA]. |
==Reference== | ==Reference== | ||
| Line 22: | Line 22: | ||
[[Category: helical bundle]] | [[Category: helical bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:56:54 2008'' |
Revision as of 11:56, 21 February 2008
|
Structure of Moloney Murine Leukaemia Virus Matrix Protein
Overview
Matrix proteins associated with the viral membrane are important in the formation of the viral particle and in virus maturation. The 1.0 A crystal structure of the ecotropic Gammaretrovirus Moloney murine leukemia virus (M-MuLV) matrix protein reveals the conserved topology of other retroviral matrix proteins, despite undetectable sequence similarity. The N terminus (normally myristylated) is exposed and adjacent to a basic surface patch, features likely to contribute to membrane binding. The four proteins in the asymmetric unit make varied contacts. The M-MuLV matrix structure is intermediate, between those of the lentiviruses and other retroviruses. The protein fold appears to be maintained, in part, by the conservation of side chain packing, which may provide a useful tool for searching for weak distant similarities in proteins.
About this Structure
1MN8 is a Single protein structure of sequence from Moloney murine leukemia virus. Full crystallographic information is available from OCA.
Reference
Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins., Riffel N, Harlos K, Iourin O, Rao Z, Kingsman A, Stuart D, Fry E, Structure. 2002 Dec;10(12):1627-36. PMID:12467570
Page seeded by OCA on Thu Feb 21 13:56:54 2008
