1mou
From Proteopedia
(New page: 200px<br /><applet load="1mou" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mou, resolution 2.2Å" /> '''Crystal structure of ...) |
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| - | [[Image:1mou.gif|left|200px]]<br /><applet load="1mou" size=" | + | [[Image:1mou.gif|left|200px]]<br /><applet load="1mou" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1mou, resolution 2.2Å" /> | caption="1mou, resolution 2.2Å" /> | ||
'''Crystal structure of Coral pigment'''<br /> | '''Crystal structure of Coral pigment'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Reef-building corals contain host pigments, termed pocilloporins, that | + | Reef-building corals contain host pigments, termed pocilloporins, that function to regulate the light environment of their resident microalgae by acting as a photoprotectant in excessive sunlight. We have determined the crystal structure of an intensely blue, nonfluorescent pocilloporin to 2.2 A resolution and a genetically engineered fluorescent variant to 2.4 A resolution. The pocilloporin chromophore structure adopts a markedly different conformation in comparison with the DsRed chromophore, despite the chromophore sequences (Gln-Tyr-Gly) being identical; the tyrosine ring of the pocilloporin chromophore is noncoplanar and in the trans configuration. Furthermore, the fluorescent variant adopted a noncoplanar chromophore conformation. The data presented here demonstrates that the conformation of the chromophore is highly dependent on its immediate environment. |
==About this Structure== | ==About this Structure== | ||
| - | 1MOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Montipora_efflorescens Montipora efflorescens] with IOD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1MOU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Montipora_efflorescens Montipora efflorescens] with <scene name='pdbligand=IOD:'>IOD</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Beddoe, T.]] | [[Category: Beddoe, T.]] | ||
| - | [[Category: Devenish, R | + | [[Category: Devenish, R J.]] |
[[Category: Dove, S.]] | [[Category: Dove, S.]] | ||
[[Category: Hoegh-Guldberg, O.]] | [[Category: Hoegh-Guldberg, O.]] | ||
[[Category: Ling, M.]] | [[Category: Ling, M.]] | ||
| - | [[Category: Oakley, A | + | [[Category: Oakley, A J.]] |
[[Category: Prescott, M.]] | [[Category: Prescott, M.]] | ||
[[Category: Rossjohn, J.]] | [[Category: Rossjohn, J.]] | ||
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[[Category: similar to green fluorescent protein and dsred]] | [[Category: similar to green fluorescent protein and dsred]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:27 2008'' |
Revision as of 11:57, 21 February 2008
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Crystal structure of Coral pigment
Overview
Reef-building corals contain host pigments, termed pocilloporins, that function to regulate the light environment of their resident microalgae by acting as a photoprotectant in excessive sunlight. We have determined the crystal structure of an intensely blue, nonfluorescent pocilloporin to 2.2 A resolution and a genetically engineered fluorescent variant to 2.4 A resolution. The pocilloporin chromophore structure adopts a markedly different conformation in comparison with the DsRed chromophore, despite the chromophore sequences (Gln-Tyr-Gly) being identical; the tyrosine ring of the pocilloporin chromophore is noncoplanar and in the trans configuration. Furthermore, the fluorescent variant adopted a noncoplanar chromophore conformation. The data presented here demonstrates that the conformation of the chromophore is highly dependent on its immediate environment.
About this Structure
1MOU is a Single protein structure of sequence from Montipora efflorescens with as ligand. Full crystallographic information is available from OCA.
Reference
The 2.2 A crystal structure of a pocilloporin pigment reveals a nonplanar chromophore conformation., Prescott M, Ling M, Beddoe T, Oakley AJ, Dove S, Hoegh-Guldberg O, Devenish RJ, Rossjohn J, Structure. 2003 Mar;11(3):275-84. PMID:12623015
Page seeded by OCA on Thu Feb 21 13:57:27 2008
