1mvg
From Proteopedia
(New page: 200px<br /><applet load="1mvg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mvg" /> '''NMR solution structure of chicken Liver basi...) |
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'''NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)'''<br /> | '''NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Chicken liver basic fatty acid binding protein (Lb-FABP) belongs to the | + | Chicken liver basic fatty acid binding protein (Lb-FABP) belongs to the basic-type fatty acid binding proteins, a novel group of proteins isolated from liver of different non mammalian species whose structure is not known. The structure of Lb-FABP has been solved by (1)H NMR. The overall fold of Lb-FABP, common to the other proteins of the family, consists of ten antiparallel beta-strands organised in two nearly ortogonal beta-sheets with two alpha helices closing the protein cavity where small hydrophobic ligands can be bound. The binding specificity of the protein is not known, however, based on the high sequence and structural similarity with an orthologous protein, ileal lipid binding protein, it is suggested that bile acids may be the putative ligands. |
==About this Structure== | ==About this Structure== | ||
| - | 1MVG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http:// | + | 1MVG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVG OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ten antiparallel beta strands]] | [[Category: ten antiparallel beta strands]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:59:24 2008'' |
Revision as of 11:59, 21 February 2008
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NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)
Overview
Chicken liver basic fatty acid binding protein (Lb-FABP) belongs to the basic-type fatty acid binding proteins, a novel group of proteins isolated from liver of different non mammalian species whose structure is not known. The structure of Lb-FABP has been solved by (1)H NMR. The overall fold of Lb-FABP, common to the other proteins of the family, consists of ten antiparallel beta-strands organised in two nearly ortogonal beta-sheets with two alpha helices closing the protein cavity where small hydrophobic ligands can be bound. The binding specificity of the protein is not known, however, based on the high sequence and structural similarity with an orthologous protein, ileal lipid binding protein, it is suggested that bile acids may be the putative ligands.
About this Structure
1MVG is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
Solution structure of chicken liver basic fatty acid binding protein., Vasile F, Ragona L, Catalano M, Zetta L, Perduca M, Monaco H, Molinari H, J Biomol NMR. 2003 Feb;25(2):157-60. PMID:12652125
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