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1n4y
From Proteopedia
(New page: 200px<br /><applet load="1n4y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n4y" /> '''REFINED STRUCTURE OF KISTRIN'''<br /> ==Ove...) |
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| - | [[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size=" | + | [[Image:1n4y.gif|left|200px]]<br /><applet load="1n4y" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1n4y" /> | caption="1n4y" /> | ||
'''REFINED STRUCTURE OF KISTRIN'''<br /> | '''REFINED STRUCTURE OF KISTRIN'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of kistrin, which is a member of a homologous family of | + | The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein. |
==About this Structure== | ==About this Structure== | ||
| - | 1N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure | + | 1N4Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Calloselasma rhodostoma]] | [[Category: Calloselasma rhodostoma]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Dennis, M | + | [[Category: Dennis, M S.]] |
[[Category: Krane, J.]] | [[Category: Krane, J.]] | ||
| - | [[Category: Krezel, A | + | [[Category: Krezel, A M.]] |
| - | [[Category: Lazarus, R | + | [[Category: Lazarus, R A.]] |
[[Category: Wagner, G.]] | [[Category: Wagner, G.]] | ||
[[Category: beta]] | [[Category: beta]] | ||
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[[Category: venom]] | [[Category: venom]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:02:16 2008'' |
Revision as of 12:02, 21 February 2008
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REFINED STRUCTURE OF KISTRIN
Overview
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
About this Structure
1N4Y is a Single protein structure of sequence from Calloselasma rhodostoma. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from OCA.
Reference
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:1862345
Page seeded by OCA on Thu Feb 21 14:02:16 2008
