1nez
From Proteopedia
(New page: 200px<br /><applet load="1nez" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nez, resolution 2.1Å" /> '''The Crystal Structure...) |
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| - | [[Image:1nez.jpg|left|200px]]<br /><applet load="1nez" size=" | + | [[Image:1nez.jpg|left|200px]]<br /><applet load="1nez" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1nez, resolution 2.1Å" /> | caption="1nez, resolution 2.1Å" /> | ||
'''The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity'''<br /> | '''The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity'''<br /> | ||
==Overview== | ==Overview== | ||
| - | TL is a nonclassical MHC class I molecule that modulates T cell activation | + | TL is a nonclassical MHC class I molecule that modulates T cell activation through relatively high-affinity interaction with CD8alphaalpha. To investigate how the TL/CD8alphaalpha interaction influences TCR signaling, we characterized the structure of the TL/CD8alphaalpha complex using X-ray crystallography. Unlike antigen-presenting molecules, the TL antigen-binding groove is occluded by specific conformational changes. This feature eliminates antigen presentation, severely hampers direct TCR recognition, and prevents TL from participating in the TCR activation complex. At the same time, the TL/CD8alphaalpha interaction is strengthened through subtle structure changes in the TL alpha3 domain. Thus, TL functions to sequester and redirect CD8alphaalpha away from the TCR, modifying lck-dependent signaling. |
==About this Structure== | ==About this Structure== | ||
| - | 1NEZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1NEZ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NEZ OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Joachimiak, A.]] | [[Category: Joachimiak, A.]] | ||
[[Category: Kronenberg, M.]] | [[Category: Kronenberg, M.]] | ||
| - | [[Category: Liu, J | + | [[Category: Liu, J H.]] |
[[Category: Liu, Y.]] | [[Category: Liu, Y.]] | ||
| - | [[Category: Naidenko, O | + | [[Category: Naidenko, O V.]] |
| - | [[Category: Reinherz, E | + | [[Category: Reinherz, E L.]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J H.]] |
[[Category: Xiong, Y.]] | [[Category: Xiong, Y.]] | ||
[[Category: Zhang, R.]] | [[Category: Zhang, R.]] | ||
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[[Category: immune system]] | [[Category: immune system]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:05:22 2008'' |
Revision as of 12:05, 21 February 2008
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The Crystal Structure of a TL/CD8aa Complex at 2.1A resolution:Implications for Memory T cell Generation, Co-receptor Preference and Affinity
Overview
TL is a nonclassical MHC class I molecule that modulates T cell activation through relatively high-affinity interaction with CD8alphaalpha. To investigate how the TL/CD8alphaalpha interaction influences TCR signaling, we characterized the structure of the TL/CD8alphaalpha complex using X-ray crystallography. Unlike antigen-presenting molecules, the TL antigen-binding groove is occluded by specific conformational changes. This feature eliminates antigen presentation, severely hampers direct TCR recognition, and prevents TL from participating in the TCR activation complex. At the same time, the TL/CD8alphaalpha interaction is strengthened through subtle structure changes in the TL alpha3 domain. Thus, TL functions to sequester and redirect CD8alphaalpha away from the TCR, modifying lck-dependent signaling.
About this Structure
1NEZ is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory., Liu Y, Xiong Y, Naidenko OV, Liu JH, Zhang R, Joachimiak A, Kronenberg M, Cheroutre H, Reinherz EL, Wang JH, Immunity. 2003 Feb;18(2):205-15. PMID:12594948
Page seeded by OCA on Thu Feb 21 14:05:22 2008
