2ch8
From Proteopedia
(New page: 200px<br /> <applet load="2ch8" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ch8, resolution 2.30Å" /> '''STRUCTURE OF THE EP...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CH8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/ | + | 2CH8 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]] with MAN and PT as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]]. |
==Reference== | ==Reference== | ||
Structure of the Epstein-Barr virus oncogene BARF1., Tarbouriech N, Ruggiero F, de Turenne-Tessier M, Ooka T, Burmeister WP, J Mol Biol. 2006 Jun 9;359(3):667-78. Epub 2006 Apr 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16647084 16647084] | Structure of the Epstein-Barr virus oncogene BARF1., Tarbouriech N, Ruggiero F, de Turenne-Tessier M, Ooka T, Burmeister WP, J Mol Biol. 2006 Jun 9;359(3):667-78. Epub 2006 Apr 18. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16647084 16647084] | ||
| - | [[Category: | + | [[Category: Human herpesvirus 4]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Burmeister, W.P.]] | [[Category: Burmeister, W.P.]] | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:25:18 2007'' |
Revision as of 11:20, 30 October 2007
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STRUCTURE OF THE EPSTEIN-BARR VIRUS ONCOGENE BARF1
Overview
The Epstein-Barr virus is a human gamma-herpesvirus that persistently, infects more than 90% of the human population. It is associated with, numerous epithelial cancers, principally undifferentiated nasopharyngeal, carcinoma and gastric carcinoma. The BARF1 gene is expressed in a high, proportion of these cancers. An oncogenic, mitogenic and immortalizing, activity of the BARF1 protein has been shown. We solved the structure of, the secreted BARF1 glycoprotein expressed in a human cell line by X-ray, crystallography at a resolution of 2.3A. The BARF1 protein consists of two, immunoglobulin (Ig)-like domains. The N-terminal domain belongs to the, subfamily of variable domains whereas the C-terminal one is related to a, constant Ig-domain. BARF1 shows an unusual hexamerisation involving ... [(full description)]
About this Structure
2CH8 is a [Single protein] structure of sequence from [Human herpesvirus 4] with MAN and PT as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of the Epstein-Barr virus oncogene BARF1., Tarbouriech N, Ruggiero F, de Turenne-Tessier M, Ooka T, Burmeister WP, J Mol Biol. 2006 Jun 9;359(3):667-78. Epub 2006 Apr 18. PMID:16647084
Page seeded by OCA on Tue Oct 30 13:25:18 2007
