2ch1
From Proteopedia
(New page: 200px<br /> <applet load="2ch1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ch1, resolution 2.40Å" /> '''STRUCTURE OF ANOPHE...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2CH1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]] with LLP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CH1 OCA]]. | + | 2CH1 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]] with LLP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2CH1 OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:25:24 2007'' |
Revision as of 11:20, 30 October 2007
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STRUCTURE OF ANOPHELES GAMBIAE 3-HYDROXYKYNURENINE TRANSAMINASE
Overview
In Anopheles gambiae, the vector for the most deadly malaria parasite, Plasmodium falciparum, xanthurenic acid (XA) plays a key role in parasite, gametogenesis and fertility. In mosquitoes, XA is produced by, transamination of 3-hydroxykynurenine (3-HK), a reaction that represents, the main route to prevent the accumulation of the potentially toxic 3-HK, excess. Interfering with XA metabolism in A. gambiae therefore appears an, attractive avenue for the development of malaria transmission-blocking, drugs and insecticides. We have determined the crystal structure of A., gambiae 3-HK transaminase in its pyridoxal 5'-phosphate form and in, complex with a newly synthesized competitive enzyme inhibitor. Structural, inspection of the enzyme active site reveals the key molecular, determinants ... [(full description)]
About this Structure
2CH1 is a [Single protein] structure of sequence from [Anopheles gambiae] with LLP and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the Anopheles gambiae 3-hydroxykynurenine transaminase., Rossi F, Garavaglia S, Giovenzana GB, Arca B, Li J, Rizzi M, Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5711-6. Epub 2006 Apr 3. PMID:16585514
Page seeded by OCA on Tue Oct 30 13:25:24 2007
