1nq3
From Proteopedia
(New page: 200px<br /><applet load="1nq3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nq3, resolution 2.2Å" /> '''Crystal structure of ...) |
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| - | [[Image:1nq3.gif|left|200px]]<br /><applet load="1nq3" size=" | + | [[Image:1nq3.gif|left|200px]]<br /><applet load="1nq3" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1nq3, resolution 2.2Å" /> | caption="1nq3, resolution 2.2Å" /> | ||
'''Crystal structure of the mammalian tumor associated antigen UK114'''<br /> | '''Crystal structure of the mammalian tumor associated antigen UK114'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The tumour-associated antigen UK114, isolated from goat liver, belongs to | + | The tumour-associated antigen UK114, isolated from goat liver, belongs to the YER057c/YIL051c/YjgF protein family, which has members in both the prokaryotes and eukaryotes. The crystal structure of a mammalian representative, goat UK114, was determined, revealing a trimeric arrangement in the crystal. It was confirmed by ultracentrifugation that UK114 is a trimer in solution. These results are in agreement with the published structures of homologues from unicellular organisms, but contrast with those reported for the rat homologue of UK114, for which a dimeric quaternary structure was proposed. |
==About this Structure== | ==About this Structure== | ||
| - | 1NQ3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http:// | + | 1NQ3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Capra_hircus Capra hircus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQ3 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Briand, C.]] | [[Category: Briand, C.]] | ||
[[Category: Deriu, D.]] | [[Category: Deriu, D.]] | ||
| - | [[Category: Grutter, M | + | [[Category: Grutter, M G.]] |
[[Category: Mistiniene, E.]] | [[Category: Mistiniene, E.]] | ||
[[Category: Naktinis, V.]] | [[Category: Naktinis, V.]] | ||
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[[Category: yer057c/yil051c/yjgf protein family]] | [[Category: yer057c/yil051c/yjgf protein family]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:08:49 2008'' |
Revision as of 12:08, 21 February 2008
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Crystal structure of the mammalian tumor associated antigen UK114
Overview
The tumour-associated antigen UK114, isolated from goat liver, belongs to the YER057c/YIL051c/YjgF protein family, which has members in both the prokaryotes and eukaryotes. The crystal structure of a mammalian representative, goat UK114, was determined, revealing a trimeric arrangement in the crystal. It was confirmed by ultracentrifugation that UK114 is a trimer in solution. These results are in agreement with the published structures of homologues from unicellular organisms, but contrast with those reported for the rat homologue of UK114, for which a dimeric quaternary structure was proposed.
About this Structure
1NQ3 is a Single protein structure of sequence from Capra hircus. Full crystallographic information is available from OCA.
Reference
Structure and oligomeric state of the mammalian tumour-associated antigen UK114., Deriu D, Briand C, Mistiniene E, Naktinis V, Grutter MG, Acta Crystallogr D Biol Crystallogr. 2003 Sep;59(Pt 9):1676-8. Epub 2003, Aug 19. PMID:12925811
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